Macrophages control systemic lipid metabolism.

• Project/Area Number: 18K16200
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Osaka University
• Principal Investigator: Kimura Tetsuya 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (40792346)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 肥満 / マクロファージ / 肥満症 / 脂肪酸 / リポ蛋白 / 脂質代謝 / 糖尿病 / 脂肪肝 / 治療

Outline of Final Research Achievements

This study examined whether macrophages, a type of immune cell, could
be a target for obesity treatment. Macrophages distribute throughout the body. Their role has been extensively studied in the immune system, such as phagocytosis of bacteria and inflammation. We examined whether macrophages could affect the flow of fat in the body and whether they are involved in developing and treating obesity. We obtained promising data that suggests modifying macrophages may be able to improve obesity.

Academic Significance and Societal Importance of the Research Achievements

マクロファージが体内の脂肪の流れと、肥満症に影響しうることがまず分かりました。今後の研究で、その詳細なメカニズムと、関与する分子を突き止めたいと考えています。マクロファージが免疫細胞としての働きだけでなく、脂質代謝にも関与できると示した点が本研究の新しい点です。最終的には肥満症の新たな治療薬として社会実装できることを目指しています。

Research Products

• [Journal Article] The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB (2022)
  • Author(s): Kimura Tetsuya、Hayama Yoshitomo、Okuzaki Daisuke、Nada Shigeyuki、Okada Masato
  • Journal Title: Journal of Biological Chemistry Volume: 298 Issue: 3 Pages: 101744-101744
  • DOI: 10.1016/j.jbc.2022.101744
  • Peer Reviewed / Open Access
• [Journal Article] The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II (2021)
  • Author(s): Nakatani Takeshi、Tsujimoto Kohei、Park JeongHoon、Jo Tatsunori、Kimura Tetsuya、Hayama Yoshitomo、Konaka Hachiro、Morita Takayoshi、Kato Yasuhiro、Nishide Masayuki、Koyama Shyohei、Nada Shigeyuki、Okada Masato、Takamatsu Hyota、Kumanogoh Atsushi
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 3333-3333
  • DOI: 10.1038/s41467-021-23654-3
  • Peer Reviewed / Open Access
• [Journal Article] p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine (2020)
  • Author(s): Ito Shizuka、Nada Shigeyuki、Yamazaki Daisuke、Kimura Tetsuya、Kajiwara Kentaro、Miki Hiroaki、Okada Masato
  • Journal Title: Cell Structure and Function Volume: 45 Issue: 2 Pages: 93-105
  • DOI: 10.1247/csf.20018
  • NAID: 130007871371
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access
• [Journal Article] SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases (2019)
  • Author(s): Maeda Yohei、Tsuda Takeshi、Takeda Y、Koyama S、Hayama Y、Nojima S、Kimura Tetsuya、Ito D、Takamatsu H、Kang S、Nishide M、Morimoto K、Hosokawa T、Kinehara Y、Kato Y、Nakatani T、Takeda K、Hayama M、Obata S、Akazawa H、Shikina T、Inohara H、Kumanogoh Atsushi
  • Journal Title: Allergology International Volume: 68 Issue: 2 Pages: 274-276
  • DOI: 10.1016/j.alit.2018.10.001
  • NAID: 130007633612
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Presentation] 肝細胞におけるLamtor1遺伝子の役割と脂質代謝への影響 (2019)
  • Author(s): 池口弘太郎、木村哲也、岡田雅人
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] マクロファージを介した肥満・脂肪肝・糖尿病予防 (2018)
  • Author(s): 木村哲也
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] Prevention of Obesity by Macrophages (2018)
  • Author(s): Tetsuya Kimura & Masato Okada
  • Organizer: 第40回 IFReCコロキウム
  • Invited