| Project/Area Number |
18K16203
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Shimane University |
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Principal Investigator |
Notsu Masakazu 島根大学, 学術研究院医学・看護学系, 助教 (50709144)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 椎体骨折 / 2型糖尿病 / 骨粗鬆症 / TGF-β / 骨折 / スクレロスチン / 糖尿病 |
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| Outline of Final Research Achievements |
We investigated TGF-β1 concentration and vertebral fracture risk in 212 male patients with type 2 diabetes mellitus. Average age 62.6 years, duration of diabetes 11.8 years, HbA1c 9.3%, respectively. The number of osteoporosis, vertebral fractures, and multiple vertebral fractures were 88, 75, and 34, respectively. Serum TGF-β1 concentration was negatively correlated with age (r = -0.25) and disease duration (r = -0.17). TGF-β1 concentration was positively correlated with BMI (r = 0.16), eGFR (r = 0.18), TRACP-5b (r = 0.19) . Serum TGF-β1 level did not correlate with bone mineral density. There was no difference in serum TGF-β1 concentration between the group with and without vertebral fracture (49580 vs 49810 pg / mL), and the group with and without osteoporosis (48505 vs 50604 pg / mL).
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| Academic Significance and Societal Importance of the Research Achievements |
今回の検討において、血中TGF-β濃度を用いた2型糖尿病における骨折リスク評価が困難であることが明らかとなった。依然として骨質劣化指標として有用な指標はなく、今後もより簡易かつ高精度に2型糖尿病患者の骨折リスクを評価する方法の開発が必要である。
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