Exploratory research to elucidate pathophysiology in diabetes and metabolic diseases

• Project/Area Number: 18K16219
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Okinaka Memorial Institute for Medical Research (2019-2023); National Center for Global Health and Medicine (2018)
• Principal Investigator: Tsujimoto Tetsuro (財)冲中記念成人病研究所, その他部局等, 研究員 (60721743)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 糖尿病 / 肥満 / 心血管疾患 / 冠動脈疾患 / 心不全 / がん / 認知症

Outline of Final Research Achievements

We reported the results of several studies using large databases: 1) In patients with HFpEF, nitrate use is inversely and significantly associated with increased risk of cardiovascular events (Tsujimoto et al. Mayo Clin Proc 2018), 2) No benefit of aspirin was found in type 2 diabetes patients with pre-existing cardiovascular disease using non-steroidal anti-inflammatory drugs (Tsujimoto et al. Diabetes Obes Metab 2019), 3) Thiazide may increase cardiovascular risk in type 2 diabetes patients with relatively low blood pressure (Tsujimoto et al. Hypertension 2019).

Academic Significance and Societal Importance of the Research Achievements

糖尿病や肥満は心血管疾患やがんなど生命予後や生活の質に関連する様々な疾患のリスクを上昇させる。糖尿病や肥満は世界中のあらゆる世代で増加しており、日本を含め世界中でその対策を講じることが必要である。さらに、これからの高齢化社会における糖尿病や肥満対策は心血管疾患だけでなく、がん、心不全、認知症への対策としても重要な意味がある。我々は大規模データベースを用いて糖尿病や代謝疾患における心血管疾患、心不全などに関する数多くの新たな知見を獲得し、論文で報告した。これらの結果はこれからの創薬標的や新規バイオマーカーにつながる可能性があり、学術的・社会的に大きく貢献するものと考えられる。

Research Products

• [Journal Article] Four-Year Screening Interval and Vision-Threatening Retinopathy in Type 2 Diabetes Patients With Good Glycemic Control (2021)
  • Author(s): Tsujimoto Tetsuro、Kajio Hiroshi
  • Journal Title: Mayo Clinic Proceedings Volume: 96 Issue: 2 Pages: 322-331
  • DOI: 10.1016/j.mayocp.2020.07.031
  • Peer Reviewed / Open Access
• [Journal Article] Spironolactone Use and Improved Outcomes in Patients With Heart Failure With Preserved Ejection Fraction With Resistant Hypertension (2020)
  • Author(s): Tsujimoto Tetsuro、Kajio Hiroshi
  • Journal Title: Journal of the American Heart Association Volume: 9 Issue: 23
  • DOI: 10.1161/jaha.120.018827
  • Peer Reviewed / Open Access
• [Journal Article] Thiazide Use and Decreased Risk of Heart Failure in Nondiabetic Patients Receiving Intensive Blood Pressure Treatment (2020)
  • Author(s): Tsujimoto Tetsuro、Kajio Hiroshi
  • Journal Title: Hypertension Volume: 76 Issue: 2 Pages: 432-441
  • DOI: 10.1161/hypertensionaha.120.15154
  • Peer Reviewed / Open Access
• [Journal Article] Use of Nitrates and Risk of Cardiovascular Events in Patients With Heart Failure With Preserved Ejection Fraction (2019)
  • Author(s): Tsujimoto Tetsuro、Kajio Hiroshi
  • Journal Title: Mayo Clinic Proceedings Volume: 94 Issue: 7 Pages: 1210-1220
  • DOI: 10.1016/j.mayocp.2018.11.032
  • Peer Reviewed / Open Access
• [Journal Article] Optimal cardiac strategy based on the history of myocardial infarction in type 2 diabetic patients with coronary artery disease. (2019)
  • Author(s): Tetsuro Tsujimoto and Hiroshi Kajio
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 3502-3502
  • DOI: 10.1038/s41598-019-39857-0
  • Peer Reviewed / Open Access
• [Journal Article] Thrombotic/Thrombolytic Balance as a Cardiac Treatment Determinant in Patients With Diabetes Mellitus and Coronary Artery Disease. (2019)
  • Author(s): Tetsuro Tsujimoto and Hiroshi Kajio
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 2
  • DOI: 10.1161/jaha.118.011207
  • Peer Reviewed / Open Access
• [Journal Article] Strategies for glycemic control in nonobese and obese type 2 diabetic patients with coronary artery disease. (2019)
  • Author(s): Tetsuro Tsujimoto and Hiroshi Kajio
  • Journal Title: International Journal of Cardiology Volume: 282 Pages: 1-6
  • DOI: 10.1016/j.ijcard.2019.02.008
  • Peer Reviewed / Open Access
• [Journal Article] No beneficial effects of aspirin on secondary cardiovascular prevention in patients with type 2 diabetes using non‐steroidal anti‐inflammatory drugs (2019)
  • Author(s): Tsujimoto Tetsuro、Kajio Hiroshi
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 8 Pages: 1978-1984
  • DOI: 10.1111/dom.13737
  • Peer Reviewed / Open Access
• [Journal Article] Thiazide Use and Cardiovascular Events in Type 2 Diabetic Patients With Well-Controlled Blood Pressure (2019)
  • Author(s): Tsujimoto Tetsuro、Kajio Hiroshi
  • Journal Title: Hypertension Volume: 74 Issue: 6 Pages: 1541-1550
  • DOI: 10.1161/hypertensionaha.119.13886
  • Peer Reviewed / Open Access
• [Journal Article] Use of Nitrates and Risk of Cardiovascular Events in Patients With Heart Failure With Preserved Ejection Fraction (2019)
  • Author(s): Tetsuro Tsujimoto and Hiroshi Kajio
  • Journal Title: Mayo Clinic Proceedings Volume: 印刷中
  • Peer Reviewed / Open Access