| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We investigated the effect of selenoprotein P on adaptive thermogenesis in brown adipose tissue and clarified the following.
(1) Selenoprotein P deficient mice exhibited higher body temperature and accumulation of sulfenylated UCP1, which is an active form, during cold exposure. (2) Noradrenaline-responsive heat generation was enhanced in selenoprotein P-deficient brown adipocytes, whereas selenoprotein P administration to brown adipocytes impaired it. (3) Administration of noradrenaline to brown adipocytes induced physiological reactive oxygen species production that stimulates heat production. Selenoprotein P has eliminated this useful reactive oxygen species.
This study revealed that selenoprotein P induces reductive stress and impairs heat production due to its excessive antioxidant capacity.
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