Venous structure created by a bio-3D printer for transplantaion

• Project/Area Number: 18K16252
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: The University of Tokyo
• Principal Investigator: Kokudo Takashi 東京大学, 医学部附属病院, 助教 (40802921)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 人工血管 / バイオ3Dプリンター / Bio-3D printer / スフェロイド

Outline of Final Research Achievements

Vascular graft was made using bio-3D printer. The vascular graft was transplanted to a pig and confirmed the patency of the graft. We are now preparing for publication.

Academic Significance and Societal Importance of the Research Achievements

本研究で作成した人工血管は臨床応用が可能となれば、今後多くの患者の治療に使用されると考えられる。

Research Products

• [Journal Article] Assessment of Preoperative Liver Function for Surgical Decision Making in Patients with Hepatocellular Carcinoma (2019)
  • Author(s): Kokudo Takashi、Hasegawa Kiyoshi、Shirata Chikara、Tanimoto Meguri、Ishizawa Takeaki、Kaneko Junichi、Akamatsu Nobuhisa、Arita Junichi、Demartines Nicolas、Uldry Emilie、Kokudo Norihiro、Halkic Nermin
  • Journal Title: Liver Cancer Volume: 8 Issue: 6 Pages: 447-456
  • DOI: 10.1159/000501368
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Albumin?Indocyanine Green Evaluation (ALICE) grade combined with portal hypertension to predict post‐hepatectomy liver failure (2019)
  • Author(s): Shirata Chikara、Kokudo Takashi、Arita Junichi、Akamatsu Nobuhisa、Kaneko Junichi、Sakamoto Yoshihiro、Kokudo Norihiro、Hasegawa Kiyoshi
  • Journal Title: Hepatology Research Volume: 印刷中 Issue: 8 Pages: 942-949
  • DOI: 10.1111/hepr.13327
  • Peer Reviewed / Open Access
• [Journal Article] A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green (2019)
  • Author(s): Inagaki Yoshinori、Kokudo Takashi、Kamiya Mako、Uno Shin-nosuke、Sato Masumitsu、Kaneko Junichi、Kokudo Norihiro、Urano Yasuteru、Hasegawa Kiyoshi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 3044-3044
  • DOI: 10.1038/s41598-019-39269-0
  • Peer Reviewed / Open Access
• [Journal Article] Hepatectomy in patients with inherited blood coagulation disorders can be safely performed with adequate coagulation factor replacement (2019)
  • Author(s): Kobayashi Kosuke、Kokudo Takashi、Yamaguchi Takamune、Shirata Chikara、Uldry Emilie、Akamatsu Nobuhisa、Arita Junichi、Kaneko Junichi、Yasumoto Atsushi、Demartines Nicolas、Hasegawa Kiyoshi、Halkic Nermin
  • Journal Title: Haemophilia Volume: 25 Issue: 3 Pages: 463-467
  • DOI: 10.1111/hae.13759
  • Peer Reviewed
• [Journal Article] Stent placement for benign portal vein stenosis following pancreaticoduodenectomy in a hybrid operating room (2018)
  • Author(s): Sawai Yutaka、Kokudo Takashi、Sakamoto Yoshihiro、Takao Hidemasa、Kazami Yusuke、Nishioka Yujiro、Akamatsu Nobuhisa、Arita Junichi、Kaneko Junichi、Hasegawa Kiyoshi
  • Journal Title: BioScience Trends Volume: 12 Issue: 6 Pages: 641-644
  • DOI: 10.5582/bst.2018.01296
  • NAID: 130007575206
  • ISSN: 1881-7815, 1881-7823
  • Year and Date: 2018-12-31
  • Peer Reviewed
• [Journal Article] Surgical treatment for monolobular Caroli's disease ‒ Report of a 30-year single center case series (2018)
  • Author(s): Yamaguchi Takamune、Cristaudi Alessandra、Kokudo Takashi、Uldry Emilie、Demartines Nicolas、Halkic Nermin
  • Journal Title: BioScience Trends Volume: 12 Issue: 4 Pages: 426-431
  • DOI: 10.5582/bst.2018.01162
  • NAID: 130007485015
  • ISSN: 1881-7815, 1881-7823
  • Year and Date: 2018-08-31
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Albumin-Indocyanine Green Evaluation Grading System Predicts Post-Hepatectomy Liver Failure for Biliary Tract Cancer (2018)
  • Author(s): Miyazaki Yoshihiro、Kokudo Takashi、Amikura Katsumi、Takahashi Amane、Ohkohchi Nobuhiro、Sakamoto Hirohiko
  • Journal Title: Digestive Surgery Volume: 36 Issue: 1 Pages: 13-19
  • DOI: 10.1159/000486142
  • Peer Reviewed
• [Journal Article] Hepatic angiomyolipoma detected using computed tomography (2018)
  • Author(s): Miyazaki Yoshihiro、Kokudo Takashi、Takahashi Amane、Amikura Katsumi、Sakamoto Hirohiko
  • Journal Title: ANZ Journal of Surgery Volume: 89 Issue: 4
  • DOI: 10.1111/ans.14156
  • Peer Reviewed
• [Journal Article] Liver Resection for Hepatocellular Carcinoma in Patients with Renal Dysfunction (2018)
  • Author(s): Shirata Chikara、Hasegawa Kiyoshi、Kokudo Takashi、Yamashita Suguru、Yamamoto Satoshi、Arita Junichi、Akamatsu Nobuhisa、Kaneko Junichi、Sakamoto Yoshihiro、Kokudo Norihiro
  • Journal Title: World Journal of Surgery Volume: 42 Issue: 12 Pages: 4054-4062
  • DOI: 10.1007/s00268-018-4698-3
  • Peer Reviewed
• [Journal Article] Liver Regeneration is Preserved After At Least Four Repeated Liver Resections for Hepatocellular Carcinoma (2018)
  • Author(s): Yamaguchi Takamune、Kokudo Takashi、Akamatsu Nobuhisa、Kaneko Junichi、Arita Junichi、Sakamoto Yoshihiro、Kokudo Norihiro、Hasegawa Kiyoshi
  • Journal Title: World Journal of Surgery Volume: 42 Issue: 12 Pages: 4070-4080
  • DOI: 10.1007/s00268-018-4714-7
  • Peer Reviewed
• [Journal Article] Innovative treatment for hepatocellular carcinoma (HCC) (2018)
  • Author(s): Kaneko Junichi、Kokudo Takashi、Inagaki Yoshinori、Hasegawa Kiyoshi
  • Journal Title: Translational Gastroenterology and Hepatology Volume: 3 Pages: 78-78
  • DOI: 10.21037/tgh.2018.10.04
  • Peer Reviewed / Open Access
• [Presentation] 肝細胞癌に対するICG蛍光法を用いた系統的肝切除術 (2019)
  • Author(s): 國土 貴嗣, 石沢 武彰, 渡邉 元己, 真木 治文, 市田 晃彦, 金子 順一, 赤松 延久, 有田 淳一, 長谷川 潔
  • Organizer: 第81回日本臨床外科学会総会
• [Presentation] 外科的見地からみた進行肝細胞癌に対する肝癌診療ガイドライン2017の検証 (2019)
  • Author(s): 國土 貴嗣、阿部 学、長谷川 潔
  • Organizer: 第55回日本肝臓学会総会
• [Presentation] 肝癌診療ガイドラインとAASLD/BCLC ガイドラインの比較検討 (2019)
  • Author(s): 國土貴嗣、石沢武彰、赤松延久、有田淳一、金子順一、長谷川潔
  • Organizer: 第119 回日本外科学会定期学術集会
• [Presentation] Assessment of Preoperative Liver Function in Patients with Hepatocellular Carcinoma (2019)
  • Author(s): Kokudo T, Shirata C, Tanimoto M, Arita J, Kaneko J, Akamatsu N, Ishizawa T, Hasegawa K
  • Organizer: APPLE2019
  • Int'l Joint Research
• [Presentation] Surgical treatment for advanced stage hepatocellular carcinoma (2018)
  • Author(s): Kokudo Takashi, Shirata Chikara, Abe Satoru, Arita Junichi, Kaneko Junichi, Akamatsu Nobuhisa, Ishizawa Takeaki, Hasegawa Kiyoshi
  • Organizer: 第80回日本臨床外科学会総会
  • Invited
• [Presentation] Digital Subtraction Angiography（DSA）を用いた ハイブリッドアンギオ室の肝胆膵外科領域における使用経験 (2018)
  • Author(s): 國土貴嗣、阪本良弘、西岡裕次郎、長田梨比人、山下俊、有田淳一、赤松延久、金子順一、大倉直樹*、高尾英正*、長谷川潔
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 進行肝細胞癌に対する肝切除の成績 (2018)
  • Author(s): 國土 貴嗣、阿部 学、長谷川 潔
  • Organizer: 第104回日本消化器病学会総会
• [Presentation] アルブミン、ICG15分値を用いた新しい肝機能評価分類（ALICE score）に基づいた肝移植適応決定 (2018)
  • Author(s): 國土貴嗣、白田力、赤松延久、金子順一、 有田淳一、阪本良弘、長谷川潔
  • Organizer: 第36回日本肝移植研究会
• [Presentation] Surgical treatment for hepatocellular carcinoma with macroscopic vascular invasion or multiple tumors (2018)
  • Author(s): Takashi Kokudo, Satoru Abe, Junichi Arita, Junichi Kaneko, Nobuhisa Akamatsu, Yoshihiro Sakamoto, Kiyoshi Hasegawa
  • Organizer: 第30回日本肝胆膵外科学会学術集会
• [Presentation] ICGを中心とした肝細胞癌の新規術前肝機能評価指標の開発 (2018)
  • Author(s): 國土貴嗣、谷本芽弘理、有田淳一、 金子順一、赤松延久、阪本良弘、長谷川潔
  • Organizer: 第54回日本肝癌研究会
• [Presentation] Assessment of preoperative liver function in patients with hepatocellular carcinoma - ALICE grade (2018)
  • Author(s): Kokudo Takashi, Miyazaki Yoshihiro, Amikura Katsumi, Takahashi Amane, Kaneko Junichi, Akamatsu Nobuhisa, Arita Junichi, Sakamoto Yoshihiro, Sakamoto Hirohiko, Hasegawa Kiyoshi
  • Organizer: 第73回 日本消化器外科学会総会
• [Presentation] Assessment of preoperative liver function in patients undergoing liver resection; The ALICE grade (2018)
  • Author(s): Kokudo Takashi, Shirata Chikara, Toda Takeo, Nishioka Yujiro, Yamaguchi Takamune, Arita Junichi, Kaneko Junichi, Akamatsu Nobuhisa, Sakamoto Yoshihiko, Hasegawa KiyoshiK
  • Organizer: 13th IHPBA World Congress
  • Int'l Joint Research
• [Book] 外科 (2018)
  • Author(s): 國土 貴嗣, 影山 優美子, 網倉 克己, 長谷川 潔, 坂本 裕彦
  • Publisher: (株)南江堂