| Project/Area Number |
18K16261
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胃癌 / マイクロRNA / signature / バイオマーカー / micro RNA |
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| Outline of Final Research Achievements |
Currently endoscopic surveillance is the gold standard for gastric cancer (GC) diagnosis, but remains as an ineffective screening strategy due to its invasiveness and associated costs. Herein, by integrating high-throughput data analysis, followed by comprehensive tissue and serum validations, we aimed to establish a circulating miRNA-based diagnostic signature for early detection of GC. We have developed a robust diagnostic marker for GC through integration of comprehensive high-throughput data analysis as well as clinical validation involving over 1200 GC samples across 6 independent cohorts. Collectively, our data demonstrates clinical significance of circulating-miRNA-signature for early detection of GC.
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| Academic Significance and Societal Importance of the Research Achievements |
現在胃癌の診断はコストが高く侵襲を伴っている。安価で非侵襲的なバイオマーカーの探索は以前からなされているが、確立されたものは少なくいわば古くて新しい課題である。本研究では、オンラインで入手可能な複数の胃癌組織の網羅的解析データファイル及びグローバルに集められた600例以上の臨床サンプルを用いて、より精度が高く侵襲の少ない胃癌診断のためのマイクロRNA signatureを開発した。本研究で得られた結果は、末梢血から早期胃癌を診断可能なバイオマーカーの開発につながる可能性がある。
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