Elucidation for epigenetic mechanism of Abscopal effect in rectal cancer after CRT
| Project/Area Number |
18K16279
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
Ide Shozo 三重大学, 医学部附属病院, 医員 (90616088)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 直腸癌 / 化学放射線療法 / アブスコパル効果 / Abscopal 効果 / Abscopal効果 |
|---|
| Outline of Final Research Achievements |
It is difficult to elucidate for abscopal effect with radiation therapy, because we could not make the mouse model with rectal cancer metastases. Otherwise, in Kaplan-Meier analysis, both overall survival (OS) and disease-free survival (DFS) were shorter in the low GNRI group, the high P-CRP group, the low LCR group, and the high RDW group in rectal cancer patients undergoing preoperative chemoradiotherapy. Our study showed that these new markers are useful to identify poor prognosis and recurrence in rectal cancer patients undergoing preoperative chemoradiotherapy.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究結果を用いることで、直腸癌化学放射線療法における新たな予後マーカーの可能性が示唆された。
|
Report
(4 results)
Research Products
(3 results)
