Development of novel gene-modified T cell transfer therapy by tumor reactivity analysis of colorectal cancer infiltrating T cells
| Project/Area Number |
18K16301
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 遺伝子改変T細胞移入療法 / 免疫療法 / 腫瘍浸潤リンパ球 / がん特異的TCR / 遺伝子改変T細胞療法 / 癌免疫療法 / T細胞 |
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| Outline of Final Research Achievements |
Analysis of tumor-infiltrating lymphocytes revealed that TCRs that proliferated clonally were present in the tumor-infiltrating lymphocytes. A specific TCR that responds to tumors cultured using the Cancer tissue-originated spheroid method could be found in the TCR.
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| Academic Significance and Societal Importance of the Research Achievements |
がん免疫療法の1つであるTCR-T細胞療法は、がん特異的TCR遺伝子を用いた遺伝子改変T細胞移入療法であるが、この療法では患者のがん細胞に特異的なTCR遺伝子が必要である。従来の方法では、TCR遺伝子の取得に多大な労力と時間を必要としていたが、今回の研究成果により簡便・迅速ながん特異的TCR遺伝子を取得することがで出来、治療効果の高い個別化TCR-T療法の臨床応用が可能となる可能性がある。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Relationship between T cell receptor clonotype and PD-1 expression of tumor-infiltrating lymphocytes in colorectal cancer.2020
Author(s)
Sukegawa K, Shitaoka K, Hamana H, Kobayashi E, Miyahara Y, Fujii K, Tsuda K, Saeki S, Nagata T, Ozawa T, Saito S, Fujii T, Muraguchi A, Shiku H, Kishi H.
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Journal Title
Eur. J. Immunol.
Volume: 50
Issue: 10
Pages: 1580-1590
DOI
Related Report
Peer Reviewed
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