• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Translational research for elucidating the clinicopathological characteristics of non-viral hepatocellular carcinoma

Research Project

Project/Area Number 18K16350
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionMie University

Principal Investigator

Kato Hiroyuki  三重大学, 医学部附属病院, 助教 (50737004)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肝細胞癌 / 細胞外マトリックス / 予後不良肝癌 / 虚血再灌流傷害 / 虚血再灌流障害 / 非ウイルス性肝癌
Outline of Final Research Achievements

We newly showed the association between the preoperative serum hyaluronic acid level and prognosis of resected patients with non-viral HCC. Despite the fact that the level of serum hyaluronic acid level is well-known marker of hepatic fibrosis, its higher level might be associated with the tumor fibrosis and poor differentiation in the non-viral HCC since background of the liver is mostly normal in such patients. Based on the results obtained, we conjectured that there might be significant association between the prognosis of non-viral HCC patients and tumor fibrosis represented by the extracellular matrix including MMP-2 and MMP-9. Our data support the future development of new treatment targeting the key-extracellular matrix.

Academic Significance and Societal Importance of the Research Achievements

ヒアルロン酸は肝線維化マーカーであるが、背景肝が正常で肝線維化が起こりにくい非ウイルス性肝癌では腫瘍の繊維性間質の量を反映している可能性がある。本研究にて非ウイルス性肝癌における線維性間質の量と予後、細胞外マトリックスであるMMP-2、MMP-9発現との関係性が示唆され、今後これらをターゲットとした治療や診断の進歩が期待される。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results)

  • [Presentation] 予後不良肝癌,いわゆるfluminant hepatocellular carcinomaの臨床的特徴とその治療成績2019

    • Author(s)
      加藤宏之
    • Organizer
      日本消化器外科学会
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi