| Project/Area Number |
18K16364
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Okayama University of Science (2019-2020)
Yamaguchi University (2018) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | cancer stem cell / autophagy / PP6 / がん幹細胞 / オートファジー / がん肝細胞 / Protein phosphatase / 肝細胞がん / Beclin 1 |
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| Outline of Final Research Achievements |
Initially, our plan was to develop an anticancer strategy to specifically inhibit autophagy in cancer stem cells by focusing on the regulatory mechanism of autophagy, which we had previously elucidated. However, as the expression of PP6, a protein phosphatase, was found to be up-regulated in cancer stem cells, I changed the goal of the project, thinking that clarifying the regulatory mechanism would lead to drug discovery targeting cancer stem cells. As a result, we found that PP6 is regulated by autophagy and that PP6 suppresses autophagy.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでにProtein phosphatase 6 (PP6)は、様々ながん種で遺伝子が変異していることや
発現が変化することが報告されており、がんにおいて重要な因子であることは認識されているがPP6発現がどのように制御されているかは全く明らかになっていなかった。本研究によりPP6の発現制御機構の一端が明らかにできたことにより、様々ながん種の発生メカニズムの解明や治療法の開発の一助となることが期待される。
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