Developing integrated approaches for the treatment of refractory tumor microenvironment
| Project/Area Number |
18K16377
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Okayama University of Science (2019)
National Cancer Center Japan (2018) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 難治性がん / 微小環境 / トランスレーショナル・リサーチ / がん微小環境 / 網羅的分子解析 / 有効化合物の同定 / 初代培養 / 化合物スクリーニング |
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| Outline of Final Research Achievements |
Non-curable tumors, including pancreatic cancer and musculoskeletal tumors, remains clinically challenging, and requires the identification of new molecular target that can be therapeutically exploited to improve patient outcome. Here, our studies demonstrate that a candidate molecule shapes the refractory tumor microenvironment through stratified experimental approaches, i.e. clinical patient data, pathological analysis, cell-molecular-genome analysis, bioinformatics, compound screening, and mouse models. The results highlight a drug suggesting a potential therapeutic strategy, “Normalization of tumor microenviroment” for mitigating refractory tumors. Thus, our new outlook suggests delivering a novel treatments, providing a hope to patients afflicted with non-curable tumors.
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| Academic Significance and Societal Importance of the Research Achievements |
今回得られた成果は、難治性のがんに苦しむ患者さんにとって、治癒のための一筋の光明となる可能性がある。
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Report
(3 results)
Research Products
(4 results)
