| Project/Area Number |
18K16382
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 55030:Cardiovascular surgery-related
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2018-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 人工心肺 / マイクロバブル / 心臓手術 / 心臓外科 / 人工肺 |
|---|
| Outline of Final Research Achievements |
In this study, experiments have been conducted to address the clinical question of whether the previously used bubble-type artificial lung can be safely reimplemented by using microbubbles.
We have confirmed that saline solution is used and that microbubble spraying increases oxygen saturation in a flow rate-dependent manner, more so than normal oxygen administration. We planned to follow this up with human blood experiments and animal studies. However, after the COVID-19 epidemic, the supply of artificial heart-lung circuits was unstable, making it difficult to purchase them for anything other than clinical use. Although we have extended the research period, the supply of artificial heart-lungs is unstable and this situation is expected to continue in FY2023; therefore, we have decided to abandon the continuation of this research, in which artificial heart-lung circuits are indispensable.
|
| Academic Significance and Societal Importance of the Research Achievements |
新生児では左心低形成症候群をはじめとする重症先天性心疾患のほか横隔膜ヘルニア、新生児呼吸促迫症候群などにより重症の循環不全、呼吸不全を発症することがあるため、気泡型人工肺が安全に人工心肺に再実装された場合には、人工心肺回路の容量を小さくすることができ、小児疾患などで問題となるプライミングボリュームの削減などが行える。このことは心臓血管外科領域において特に高い学術的意義、臨床的意義があると考えられる。
|
