| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Stem cell therapy using adipose tissue-derived mesenchymal stem cells for refractory lung diseases, using a three-dimensional culture method of stem cells in cell-free pulmonary interstitium that maintains the organ skeleton, we presented findings on the spatiotemporal dynamics of transplanted stem cells in the lung interstitium and the possibility of improving the fixation rate of stem cells in the lung tissue through combined administration with alveolar epithelial cells. The possibility of improving the fixation rate of stem cells in lung tissue by combined administration with alveolar epithelial cells was also demonstrated. We also showed that in vitro combined co-culture of mesenchymal stem cells and alveolar epithelial cells enhances cell-to-cell junctions and mass diffusion effects, thereby strengthening the barrier function of the air-blood barrier.
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