Recovery of endogenous analgesic function by antidepressants and its usefulness for persistent postoperative pain
| Project/Area Number |
18K16436
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Gunma University |
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Principal Investigator |
Ohta Jo 群馬大学, 医学部附属病院, 助教 (30761100)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 神経障害性疼痛 / 術後痛 / ノルアドレナリン作動性神経系 / 術後痛モデル / アミトリプチリン / ノルアドレナリン作動性神経 / 内因性鎮痛機能 / 性コリン作動性神経系 / ムスカリン性コリン作動性神経系 / 脊髄後角 / 遷延性術後痛 / 抗うつ薬 |
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| Outline of Final Research Achievements |
In rats with neuropathic pain in the chronic phase, the newly added plantar incision caused prolonged pain. The analgesic effects of the noradrenergic and muscarinic cholinergic nervous systems, which are important in the recovery process of normal postoperative pain, were lost in these animals. Continuous administration of the antidepressant amitriptyline for 5 days was able to restore the attenuated endogenous analgesic function in the medium term. Perioperative administration of amitriptyline for 13 consecutive days improved the prolongation of pain after plantar incision, but the mechanism significantly involved the muscarinic cholinergic nervous system rather than the noradrenergic nervous system.
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| Academic Significance and Societal Importance of the Research Achievements |
術後痛の正常な回復過程にはノルアドレナリン作動性神経系を含めた内因性鎮痛機能による鎮痛が作用している。慢性痛を抱えている場合には、内因性鎮痛機能機能が減弱化しているために、術後痛が遷延化する可能性がある。抗うつ薬アミトリプチリンには内因性鎮痛機能を賦活化させる作用があるため、抗うつ薬の周術期投与は術後痛の遷延化予防に役立つ可能性がある。
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Report
(4 results)
Research Products
(5 results)
