Association between nutrition and ICU - acquired weakness : a prospective cohort study.

• Project/Area Number: 18K16439
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Masuda Takahiro 東京医科歯科大学, 東京医科歯科大学病院, 助教 (40594635)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 集中治療医学 / 気道確保 / 栄養療法 / 集中治療 / 集中治療後症候群 / 敗血症

Outline of Final Research Achievements

Nutrition therapy is regarded as an important role in longitudinal outcome of critically ill patients, but the effect of nutrition therapy on clinical outcome is unknown. This study is conducted to reveal the association between them, but the study is faced to the difficulty in the pandemic of Corona Virus Infectious Disease 2019 (CoVID-19), because exhaled gas, which is needed in this study becomes not available.
In this difficulty, I decided to change the plan of study, and I conducted the retrospective observational cohort study, which revealed the association between airway management techniques and peri-intubation complications.

Academic Significance and Societal Importance of the Research Achievements

結果的にこの研究では当初計画していた栄養療法の研究を遂行することはできなかったが、代替として実施した気道確保の研究で、意識下挿管が気管挿管に伴って発生する重篤な合併症を大幅に予防しうることを見出すことができた。重症症例における気道確保は、栄養療法と同じ程度に重要な研究課題であることから、本研究をきっかけとして、軌道確保、特に意識下挿管が重症症例にもたらす影響について、今後研究を発展させる方針である。

Research Products

• [Journal Article] Case of laryngeal venous malformations requiring repeated advanced airway management in the perioperative course (2022)
  • Author(s): Maruyama Fumi、Masuda Takahiro、Nosaka Nobuyuki、Wakabayashi Kenji
  • Journal Title: Clinical Case Reports Volume: 10 Issue: 12
  • DOI: 10.1002/ccr3.6687
  • Peer Reviewed / Open Access
• [Journal Article] Sedation and Ventilator Liberation Protocol vs Usual Care and Duration of Invasive Ventilation in Pediatric Intensive Care Units (2021)
  • Author(s): Nosaka Nobuyuki、Masuda Takahiro
  • Journal Title: JAMA Volume: 326 Issue: 22 Pages: 2328-2328
  • DOI: 10.1001/jama.2021.17728
• [Journal Article] COVID-19 case of ventilator-induced lung injury on extracorporeal membrane oxygenation: Physicians' clinical struggle and ethical conflict in a novel pandemic (2021)
  • Author(s): Yoshiko Ishisaka, Nobuyuki Nosaka, Yuka Mishima, Takahiro Masuda, Michio Nagashima, Yosuke Tanaka, Kouhei Yamamoto, Masayuki Yoshida, Hidenobu Shigemitsu
  • Journal Title: Clinical Case Reports Volume: 8 Issue: 12
  • DOI: 10.1002/ccr3.5223
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of multidisciplinary team approach with extracorporeal membrane oxygenation for COVID-19 in a low volume ECMO center (2021)
  • Author(s): Eiki Nagaoka, Hirokuni Arai, Toyomu Ugawa, Takahiro Masuda, Kanae Ochiai, Meiyo Tamaoka, Naoki Kurashima, Keiji Oi, Tatsuki Fujiwara, Masayuki Yoshida, Hidenobu Shigemitsu, Yasuhiro Otomo
  • Journal Title: Artificial organs Volume: 45 Issue: 9 Pages: 1061-1067
  • DOI: 10.1111/aor.13947
  • Peer Reviewed / Open Access
• [Journal Article] Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients (2021)
  • Author(s): Masuda Takahiro、Nosaka Nobuyuki、Nagashima Michio
  • Journal Title: JAMA Volume: 326 Issue: 6 Pages: 568-568
  • DOI: 10.1001/jama.2021.8529
• [Journal Article] Use of stylet and airway management procedure in critically ill patients (2021)
  • Author(s): Masuda Takahiro、Nosaka Nobuyuki、Uchimido Ryo、Nagashima Michio
  • Journal Title: Intensive Care Medicine Volume: 47 Issue: 12 Pages: 1497-1498
  • DOI: 10.1007/s00134-021-06476-1
• [Journal Article] Prognostic impact of sustained new-onset atrial fibrillation in critically ill patients (2020)
  • Author(s): Yoshida T, Uchino S, Sasabuchi Y, Hagiwara Y, Yoshida T, Nashiki H, Suzuki H, Takahashi H, Kishihara Y, Nagasaki S, Okazaki T, Katayama S, Sakuraya M, Ogura T, Inoue S, Uchida M, Osaki Y, Kuriyama A, Irie H, Kyo M, Shima N, Saito J, Nakayama I, Jingushi N, Nishiyama K, Masuda T,
  • Journal Title: Intensive Care Med Volume: 46 Issue: 1 Pages: 27-35
  • DOI: 10.1007/s00134-019-05822-8
  • Peer Reviewed
• [Journal Article] Oxygen management in mechanically ventilated patients: A multicenter prospective observational study (2018)
  • Author(s): Egi M, Kataoka J, Ito T, et al.
  • Journal Title: J Crit Care. Volume: 21 Pages: 1-5
  • DOI: 10.1016/j.jcrc.2018.03.024
  • Peer Reviewed
• [Presentation] 重症症例への気管挿管において、意識下挿管は有害事象の発生率低下と関連する (2024)
  • Author(s): 西郷茉優、増田孝広、若林健二
  • Organizer: 第51回日本集中治療医学会学術集会
• [Presentation] Effect of ramelteon on reducing in-hospital mortality in critically ill adults: a nationwide observational cohort study in Japan (2022)
  • Author(s): Takeuchi T, Inoue N, Masuda T, Fushimi K.
  • Organizer: International Symposium on Intensive Care and Emergency Medicine
  • Int'l Joint Research
• [Presentation] ICUにおける手指衛生に関係する因子の検討 看護必要度との関連 (2019)
  • Author(s): 飯嶋 正子, 横倉 千恵子, 小池 正朗, 石川 潮音, 高橋 洋子, 増田 孝広, 石垣 裕美, 西 奈緒
  • Organizer: 第46回日本集中治療医学会学術集会
• [Presentation] RRSに期待される医療安全との連携-次世代に向けた新しい流れ- Rapid Response System(RRS)で対応した患者のCode Statusに関する報告 (2019)
  • Author(s): 高橋 英夫, 長島 道生, 落合 香苗, 高橋 洋子, 我満 幸子, 塩田 修玄, 増田 孝広, 若林 健二, 大友 康裕, 重光 秀信
  • Organizer: 第46回日本集中治療医学会学術集会
• [Presentation] 心臓血管外科領域における周術期の蛋白摂取量が術後在院日数に及ぼす影響についての検討 (2018)
  • Author(s): 増田 孝広,清水 行栄,大石 純子,斎藤 恵子
  • Organizer: 第33回日本静脈経腸栄養学会学術集会
• [Presentation] ECMO にて加療した子宮頸癌を原発とする pulmonary tumor thrombotic microangiopathy の 1 例 (2018)
  • Author(s): 増田 孝広,塩田 修玄,丸山 史,若林 健二,高橋 英夫,重光 秀信
  • Organizer: 第45回日本集中治療医学会学術集会