| Project/Area Number |
18K16449
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 慢性痛 / 脳機能的結合 / functional MRI / ケタミン / MRI / functional connectivity |
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| Outline of Final Research Achievements |
Ketamine has been used to treat chronic pain; however, it is still unknown as to what types of chronic pain is ketamine effective against. To identify the effect of administration of subanesthetic-dose ketamine in patients with chronic pain and to clarify the mechanism of the effect, we retrospectively investigated brain functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI). Patients were divided into responders and non-responders (Group NR). We compared the differences in terms of brain functional connectivity by seed-to-voxel correlation analysis. Two-sample t-test revealed significant lower connectivity between the medial prefrontal cortex (mPFC) and precuneus in Group R. We also found a significant negative correlation between the improvement rate and functional connectivity strength between the mPFC and precuneus.
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| Academic Significance and Societal Importance of the Research Achievements |
近年functional MRI(fMRI)でヒト、動物の中枢神経活動に関連した血流動態反応を評価する研究がすすめられており、健常人と比較して慢性痛患者やうつ病患者などで、脳機能的結合が変化している事が報告されている。また近年ケタミンの即効性・持続性の抗うつが世界的に注目されている。さらにケタミンはうつ病患者の臨床症状を改善させ、かつ脳機能的結合の変化を急速に正常化させる事が報告されている。
ケタミンは以前から痛みの治療に用いられているが、慢性痛患者におけるケタミンの脳機能的結合への影響の報告はまだ無く、本研究はその初期の知見になりうる。
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