| Project/Area Number |
18K16467
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
WANG HAN-YING 沖縄科学技術大学院大学, 細胞分子シナプス機能ユニット, 研究員 (70814333)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Isoflurane / calyx of Held / capacitance measurement / exo-endocytosis / neurotransmission / Calyx of Held / Cerebral cortex / Presynaptic reocrding / Capacitance / Action potential / exocytic machinery / Ion channels / Fidelity |
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| Outline of Final Research Achievements |
Synaptic mechanisms of general anesthesia remain unidentified. In rat brainstem slices, isoflurane inhibits excitatory transmitter release by blocking presynaptic calcium channels and exocytic machinery, with the latter mechanism predominating in its inhibitory effect on high-frequency transmission. Both in slice and in vivo, isoflurane preferentially inhibits spike transmission induced by high-frequency presynaptic inputs. This low-pass filtering action of isoflurane likely plays a significant role in general anesthesia.
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| Academic Significance and Societal Importance of the Research Achievements |
We discovered isoflurane preferentially inhibits high-frequency neurotransmission, therefore, selective inhibition by volatile anesthetics of high-frequency transmission will effectively attenuate such integral neuronal functions, with minimal inhibition of basal neuronal functions.
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