| Project/Area Number |
18K16473
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | オピオイド / 痛覚過敏 / 小胞体ストレス / 吸入麻酔薬 / オピオイド誘発性疼痛過敏 / 変異BiPノックインマウス / 化学シャペロン / シャペロン / マウス / 虚血 / 低酸素 |
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| Outline of Final Research Achievements |
Although different from the original plan, we created a pain-sensitive model mouse by intermittently administering remifentanil to wild-type mice, and examined the effect of endoplasmic reticulum stress on opioid-induced hyperalgesia (OIH). An experiment was conducted. It was suggested that administration of chemical chaperones such as Sodium phenylbutyrate (4-PBA) and Tauroursodeoxycholic acid (TUDCA) to pain-sensitive model mice may suppress pain-sensitivity.
We also studied the neuroprotective effect of inhalational anesthetics, neurotoxicity, and endoplasmic reticulum stress, and published it as a paper.
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| Academic Significance and Societal Importance of the Research Achievements |
オピオイドはがん疼痛などに非常に有用な鎮痛薬であるが、乱用による中毒や副作用が問題となることもある。オピオイド投与によって誘発される疼痛過敏(opioid induced hyperalgesia:OIH)は、まだメカニズムが不明な部分も多く、治療法も確立されていない。我々の研究は、OIHと小胞体ストレス反応の関連を明らかにし、化学シャペロンの投与によってOIHが抑制される可能性を示唆している。
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