Postoperative cognitive dysfunction and the prevention in type 2 diabetes mellitus model mice

• Project/Area Number: 18K16480
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kobe University
• Principal Investigator: Nishimura Momoka 神戸大学, 医学部附属病院, 医員 (70803857)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 2型糖尿病モデルマウス / 周術期合併症 / ノルアドレナリン / 術後認知機能障害 / 術後せん妄 / 周術期行動変化 / Surgical stress / Type 2 diabetes mellitus / Hyperactive behavior / 2型糖尿病 / 手術侵襲 / 術後の活動性変化 / 糖尿病 / 高脂肪食 / 認知機能障害

Outline of Final Research Achievements

The purpose of the present study was to reveal mechanism of postoperative cognitive dysfunction in diabetes mellitus. We examined the effects of surgical stress on postoperative behavioral activity in type 2 diabetes mellitus model mice fed high fat diet. Perioperative behavioral activities, hippocampal mRNA expression of β adrenaline receptor and noradrenaline level were measured. In our study, type 2 diabetes mellitus model mice showed lower activity after abdominal surgery compared to before surgery. And the hippocampal noradrenaline level also decreased after surgery. These finding may indicate that surgical stress had a suppressive effect on behavioral activity and hippocampal noradrenaline in type 2 diabetes mellitus model mice.

Academic Significance and Societal Importance of the Research Achievements

昨今、糖尿病患者は増加し続けており、手術を受ける糖尿病患者も増加している。糖尿病は周術期における術後認知機能障害のリスク因子であり、予後不良に繋がるが、その病態機序は未だ明らかではない。本研究結果から2型糖尿病モデルマウスにおいて、手術侵襲は術前に比較して術後の活動性を低下させ、海馬のノルアドレナリン濃度を減少させた。よって、糖尿病の病態において手術侵襲は行動と海馬のノルアドレナリン濃度に抑制的な影響を及ぼす可能性が示唆された。今後、糖尿病患者における術後せん妄など周術期の精神活動変化への研究に繋がる可能性がある。

Research Products

• [Journal Article] Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice (2020)
  • Author(s): Nishimura Momoka、Nomura Yuki、Egi Moritoki、Obata Norihiko、Tsunoda Makoto、Mizobuchi Satoshi
  • Journal Title: BMC Neuroscience Volume: 21 Issue: 1 Pages: 1-10
  • DOI: 10.1186/s12868-020-0556-y
  • NAID: 120006813336
  • Peer Reviewed / Open Access
• [Presentation] 2型糖尿病マウスにおける術後低活動性と周術期脳内モノアミン受容体発現量の変化 (2019)
  • Author(s): 東南杏香、野村有紀、江木盛時、小幡典彦、溝渕知司
  • Organizer: 日本麻酔科学会第66回学術集会
• [Presentation] Postoperative Hypoactivities and Decrease of Hippocampal Catecholamine in Type 2 Diabetes Model Mice (2019)
  • Author(s): Momoka Nishimura, Yuki Nomura, Moritoki Egi, Norihiko Obata, Makoto Tsunoda, Satoshi Mizobuchi
  • Organizer: American Society of Anesthesiologist 2019
  • Int'l Joint Research