| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The purpose of this study was to examine the contribution of TRPA1 to cancer-induced pain by using a mouse model of cancer pain. Mice were subcutaneously injected a solution of Lewis lung carcinoma in the left plantar region. In a mouse model of cancer pain, the volumes of inoculated hind paws, spontaneous pain and mechanical and thermal hyperalgesia gradually increased throughout the observation period. Tumor growth and spontaneous pain were significantly suppressed in TRPA1 gene-deficient mice compared with wild-type mice. Mechanical and thermal hyperalgesia were comparable to wild-type mice. This study showed that TRPA1 is involved in tumor growth and spontaneous cancer pain-related behaviors but not in cancer induced mechanical and thermal hyperalgesia.
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