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The role of TRPA1 in cancer pain

Research Project

Project/Area Number 18K16493
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55050:Anesthesiology-related
Research InstitutionWakayama Medical University

Principal Investigator

Yoshida Akari  和歌山県立医科大学, 医学部, 助教 (40584777)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsTRPA1 / がん性痛
Outline of Final Research Achievements

The purpose of this study was to examine the contribution of TRPA1 to cancer-induced pain by using a mouse model of cancer pain. Mice were subcutaneously injected a solution of Lewis lung carcinoma in the left plantar region. In a mouse model of cancer pain, the volumes of inoculated hind paws, spontaneous pain and mechanical and thermal hyperalgesia gradually increased throughout the observation period. Tumor growth and spontaneous pain were significantly suppressed in TRPA1 gene-deficient mice compared with wild-type mice. Mechanical and thermal hyperalgesia were comparable to wild-type mice. This study showed that TRPA1 is involved in tumor growth and spontaneous cancer pain-related behaviors but not in cancer induced mechanical and thermal hyperalgesia.

Academic Significance and Societal Importance of the Research Achievements

本研究では、がん性痛の末梢機序についてこれまで研究されていないTRPA1に注目した。結果、TRPA1遺伝子欠損マウスで作製した足底がん性痛モデルでは、野生型マウスと比較して腫瘍増殖および自発痛関連行動が有意に抑制されることが明らかとなった。TRPA1は主に末梢痛覚神経に発現しているため、TRPA1の機能抑制は中枢性の副作用のない鎮痛法開発につながる可能性が高い。TRPA1拮抗薬とオピオイドの併用により、オピオイドの投与量を減じても優れた鎮痛効果が得られ、かつ、オピオイドによる副作用を減じることが可能となりうる。これらはがん患者のQOL向上に大きく貢献すると考えられ、社会的意義は大きい。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 食道アカラシアに対する経口内視鏡的筋層切開術中に気胸による重篤な循環虚脱と換気不全を生じた1症例2020

    • Author(s)
      大島智子、吉田朱里、山﨑亮典、川股知之
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 40 Issue: 4 Pages: 349-352

    • DOI

      10.2199/jjsca.40.349

    • NAID

      130007891344

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of noninvasive continuous arterial pressure measurement by ClearSight System during induction of anesthesia for cardiovascular surgery2020

    • Author(s)
      Tanioku Tadashi、Yoshida Akari、Aratani Yuichi、Fujii Keisuke、Kawamata Tomoyuki
    • Journal Title

      BMC Anesthesiology

      Volume: 20 Issue: 1 Pages: 176-183

    • DOI

      10.1186/s12871-020-01091-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Severe circulatory collapse and respiratory failure due to pneumothorax during peroral endoscopic myotomy for treatment of esophageal achalasia2020

    • Author(s)
      Yoshida A, Ohmori Y, Shiozaki T, Yoshida H, Kawamata T
    • Organizer
      Annual meeting of the American Society of Anesthesiologists
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPV1 is involved in both tumor growth and cancer-induced pain2020

    • Author(s)
      Yoshida A, Kawamata T
    • Organizer
      International Symposium on TRP Ion Channel at Wakayama
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がんに伴う痛み刺激はTRPV1を介して腫瘍増殖を促進する2020

    • Author(s)
      吉田朱里、谷奥匡、荒谷優一、丸山智之、川股知之
    • Organizer
      日本麻酔科学会第67回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] がん性痛モデル2020

    • Author(s)
      吉田朱里、川股知之
    • Organizer
      日本ペインクリニック学会第54回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] TRPA1はがんの増殖を促進する2019

    • Author(s)
      吉田朱里、谷奥 匡、川股知之
    • Organizer
      日本神経麻酔集中治療学会
    • Related Report
      2018 Research-status Report
  • [Presentation] TRPA1 is involved in cancer-induced spontaneous pain but not mechanical and thermal hyperalgesia2018

    • Author(s)
      Yoshida A, Ogawa S, Tazoe M, Kawamata T
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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