| Project/Area Number |
18K16514
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 熱中症 / HMGB1 / 救急医学 |
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| Outline of Final Research Achievements |
We tried to clarify mechanism or risk factors of heatstroke encephalopathy by registry data, animal experimentation, and clinical research. (1)Registry data: In multivariate analysis, type of heatstroke, GCS, and platelets were independent predictors of poor neurological outcome. (2)Animal experimentation: In rat heatstroke model, CSF HMGB1 was higher than serum HMGB1. And CSF HMGB1 was significantly higher than control. (3)Clinical research: In heatstroke patient, serum HMGB1 did not predict neurological outcome.
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| Academic Significance and Societal Importance of the Research Achievements |
近年熱中症患者が激増しており、特に高齢者の熱中症後の神経学的後遺症は社会的に大きな問題となっている。熱中症の中枢神経障害発症のメカニズムやリスク因子は従来明らかでなく、本研究でその一端を明らかにすることができた。本研究の結果は今後の熱中症の新たな検査や治療法開発の第一歩となりうる。
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