| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Mouse bone marrow-derived mesenchymal stem cells (MSCs) were generated using C57BL/6 mice (8-9 weeks old). In a mouse model of severe burn injury (20% TBSA) using the hot water, 100μl of MSC culture supernatant was injected intravenously for five consecutive days immediately after burn injury. Gross analysis of burn skin was performed 7, 14 and 21 days after burn injury. The results showed that localised burn skin lesions tended to improve grossly in the MSC culture supernatant-treated group compared to the saline-treated control group. It was suggested that the administration of MSC culture supernatant may allow early healing of severe burns.
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