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A multi-drug compatibility test based on injection drug use in an emergency center and its clinical application

Research Project

Project/Area Number 18K16547
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionNippon Medical School

Principal Investigator

Kondo Masayoshi  日本医科大学, 医学部, 主任 (60795730)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords配合変化試験 / 濁度 / HPLC / 集中治療 / 注射薬 / 多剤配合変化試験 / 配合変化 / pH / 注射 / 残存率
Outline of Final Research Achievements

The study is to conduct a multi-drug compatibility test based on the use of injectable drugs in the emergency and intensive care. Then, a multi-drug compatibility chart should be created and used clinically. The 3-drug compatibility test was conducted in 157 tests, revealing that the combination of “rocuronium - insulin human - heparin” caused incompatibility. In addition, it was clarified that combination of vasopressin and catecholamine drugs decreased the content of vasopressin. In addition, we clarified that sodium sulfite, an additive for catecholamine drugs, reduces the residual drug rate of vasopressin. From these compatibility tests, we created the compatibility chart and succeeded in using it clinically.

Academic Significance and Societal Importance of the Research Achievements

救急・集中治療領域では、多くの注射薬が同一ルート内で配合されて投与されており、配合変化の危険性が高い。同一ルートで投与できるか判断するために配合変化試験を実施して評価し、その試験情報をデータベース化し医療現場へ還元した。本結果により、安全な注射薬の点滴ルート選択を実施することができ、より効果的で安全な薬物療法の提供が可能となった。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2022 2021 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (8 results)

  • [Journal Article] Utility of a Compatibility Chart for Continuous Infusions in the Intensive Care Unit2022

    • Author(s)
      Kondo Masayoshi、Tanaka Chie、Tagami Takashi、Nagano Makihiko、Sugaya Kazutoshi、Tagui Naoya、Kaneko Junya、Kudo Saori、Kuno Masamune、Unemoto Kyoko、Takase Hisamitsu
    • Journal Title

      Journal of Nippon Medical School

      Volume: 89 Issue: 2 Pages: 227-232

    • DOI

      10.1272/jnms.JNMS.2022_89-220

    • ISSN
      1345-4676, 1347-3409
    • Year and Date
      2022-04-25
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physical compatibility of remimazolam with opioid analgesics, sedatives, and muscle relaxants during simulated Y-site administration2022

    • Author(s)
      Kondo Masayoshi、Yoshida Naoki、Yoshida Mariko、Tanaka Chie、Tagami Takashi、Horikawa Kazumi、Sugaya Kazutoshi、Takase Hisamitsu
    • Journal Title

      American Journal of Health-System Pharmacy

      Volume: 80 Issue: 1 Pages: e53-e58

    • DOI

      10.1093/ajhp/zxac262

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical Compatibility of Nafamostat with Analgesics, Sedatives, and Muscle Relaxants for Treatment of Coronavirus Disease 20192021

    • Author(s)
      Kondo Masayoshi、Nagano Makihiko、Yoshida Mariko、Yoshida Naoki、Tagui Naoya、Yoshida Masato、Sugaya Kazutoshi、Takase Hisamitsu
    • Journal Title

      Journal of Nippon Medical School

      Volume: 88 Issue: 6 Pages: 533-539

    • DOI

      10.1272/jnms.JNMS.2022_89-104

    • NAID

      130008137763

    • ISSN
      1345-4676, 1347-3409
    • Year and Date
      2021-12-25
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 配合変化試験に基づく3剤配合変化早見表の作成2021

    • Author(s)
      近藤匡慶
    • Organizer
      日本医科大学医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 臨床応用に向けたヘパリン注とランジオロール注及びニコランジル注を基本配合とした3剤配合変化試験2020

    • Author(s)
      近藤匡慶
    • Organizer
      日本臨床救急医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] COVID-19を想定としたナファモスタット注射薬における院内配合変化試験による情報提供2020

    • Author(s)
      吉田茉莉子、近藤匡慶
    • Organizer
      日本医科大学医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 注射薬添加物による化学的配合変化の検討~バソプレシンはカテコールアミン系薬剤の添加物で含有量が低下する~2019

    • Author(s)
      近藤匡慶
    • Organizer
      第87回日本医科大学医学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 濁度を指標としたヘパリン注射薬とフロセミド注射薬を基本配合とした3剤配合変化試験の実施2019

    • Author(s)
      近藤匡慶
    • Organizer
      第29回日本医療薬学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 注射薬配合変化試験データの臨床上の有用性~臨床治療に有用なデータ構築に向けて~2019

    • Author(s)
      長谷川茉莉子、近藤匡慶
    • Organizer
      医療薬学フォーラム2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 数値で見る注射剤の配合変化 濁度計を用いた配合変化の測定 ヘパリンナトリウムとドブタミンの配合変化を例として2019

    • Author(s)
      深尾彰平、近藤匡慶
    • Organizer
      第40回日本臨床薬理学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 救命救急センターにおける持続性注射薬の使用状況に基づく多剤配合試験へのHPLC分析法の適用と評価2018

    • Author(s)
      玉木 綾音 近藤 匡慶
    • Organizer
      医療薬学フォーラム2018 第26回クリニカルファーマシーシンポジウム
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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