Development of Oncolytic virus by passaging in vivo mouse glioma model
Project/Area Number |
18K16560
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56010:Neurosurgery-related
|
Research Institution | Okayama University |
Principal Investigator |
Fujii Kentaro 岡山大学, 医歯薬学総合研究科, 助教 (40799318)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | グリオーママウスモデル / 腫瘍溶解性ウイルス |
Outline of Final Research Achievements |
Malignant gliomas are among the most common types of brain tumor, and the prognosis remains extremely poor. Oncolytic viral therapy is expected as a new treatment modality for malignant glioma. In this study, we tried to produce a new oncolytic virus with powerful effect for glioma therapy by passaging virus in vivo instead of genetically engineering. Passaged viruses are not more toxic, and it suggests that passaged viruses could be more effective for glioma therapy than parent strains. We intend to continue this study to accumulate data.
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Academic Significance and Societal Importance of the Research Achievements |
他臓器の悪性腫瘍において、非常に効果的な治療法が開発されている一方で、悪性グリオーマの予後は集学的治療を行っても、依然として極めて不良である。腫瘍溶解性ウイルスは悪性グリオーマに対する新たな治療法として期待されているが、より強力な腫瘍溶解性ウイルスが開発されれば、悪性グリオーマの新規治療法として、研究や臨床においてbreakthroughになりうる。
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Report
(4 results)
Research Products
(125 results)
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[Journal Article] Pyogenic ventriculitis after anterior skull base surgery treated with endoscopic ventricular irrigation and reconstruction using a vascularized flap2021
Author(s)
Tomita Y , Shimazu Y , Kawakami M , Matsumoto H , Fujii K , Kameda M , Yasuhara T , Suruga Y , Ota T , Kimata Y , Kurozumi K , Date I
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Journal Title
Acta Medica Okayama
Volume: 75(2)
Pages: 243-248
NAID
Related Report
Peer Reviewed
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[Journal Article] Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration2021
Author(s)
Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I.
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Journal Title
Acta Neuropathol Commun.
Volume: 9
Issue: 1
Pages: 29-29
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma2020
Author(s)
Matsumoto Y , Ichikawa T , Kurozumi K , Otani Y , Fujimura A , Fujii K , Tomita Y , Hattori Y , Uneda A , Tsuboi N , Kaneda K , Makino K , Date I
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Journal Title
Acta Neuropathologica Communications
Volume: ー
Issue: 1
Pages: 42-42
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Detailed arterial anatomy and its anatomoses of the sphenoid ridge and olfactory groove meningiomas with special reference to the recurrent branches from the ophthalmic artery2020
Author(s)
Hiramatsu M , Sugiu K , Hishikawa T , Haruma J , Takahashi Y , Murai S , Nishi K , Yamaoka Y , Shimazu Y , Fujii K , Kameda M , Kurozumi K , Date I
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Journal Title
AJNR Americal Journal of Neuroradiology
Volume: 41(11)
Issue: 11
Pages: 2082-2087
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of aspergillotic orbital apex syndrome diagnosed by an additional intraorbital biopsy after nasal endoscopy2018
Author(s)
Matsumoto N , Sato K , Tadokoro K, Takahashi Y , Yunoki T , Takemoto M , Hishikawa N , Ohta Y , Yamashita T , Fujii K , Ichikawa T , Date I , Abe K
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Journal Title
Neurology and Clinical Neuroscience
Volume: 6
Pages: 188-190
Related Report
Peer Reviewed
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[Presentation] Vasculostatin-armed oncolytic herpes virus decreased bevacizumab-induced glioma invasion by regulating CCN1 and AKT signaling pathway2019
Author(s)
Tomita Y , Kurozumi K , Yoo JY , Fujii K , Ichikawa T , Matsumoto Y , Uneda A , Hattori Y , Otani Y , Kaur B , Date I
Organizer
第25回日本遺伝子細胞治療学会
Related Report
Int'l Joint Research
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[Presentation] The current status of Ad-SGE-REIC gene therapy for malignant glioma2019
Author(s)
Kurozumi K , Fujii K , Oka T , Hattori Y , Tomita Y , Uneda A , Matsumoto Y , Tsuboi N , Kaneda K , Makino K , Kumon H , Date I
Organizer
24rd Annual Meeting and Education Day of the Society for Neuro-Oncology
Related Report
Int'l Joint Research
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[Presentation] A phenotypic transition of glioma cells via the ANXA2-STAT3-OSMR axis2019
Author(s)
Matsumoto Y , Ichikawa T , Kurozumi K , Otani Y , Fujimura A , Fujii K , Shimazu Y , Tomita Y , Hattori Y , Uneda A , Tsuboi N , Kaneda K , Makino K , Date I
Organizer
2019 Congress of Neurological Surgeons Annual Meeting: CNS2019
Related Report
Int'l Joint Research
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