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Aging-associated inflammation and fibrosis in arachnoid membrane.

Research Project

Project/Area Number 18K16591
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionSapporo Medical University

Principal Investigator

SUZUKI HIME  札幌医科大学, 医学部, 研究員 (30815452)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsくも膜 / 慢性炎症 / 慢性脳虚血 / 動脈硬化 / 慢性虚血性変化 / 加齢 / 虚血性脳疾患
Outline of Final Research Achievements

The physiological and pathological significance of the arachnoid membrane (AM) is still unknown. In this study, we investigated various characteristics of the AM, focusing on the influence of inflammation and fibrosis. Small pieces of AM sample were obtained during neurosurgical procedures from 74 cases. The clinical and pathological characteristics of the hyperplastic AM group and the non-hyperplastic AM group were compared. Then, potential correlations between AM thickness and clinical characteristics were analyzed. Moreover, VEGFα, TGFβ, and TGFα levels were quantitated by real time PCR. The AM hyperplasia was influenced by aging and could be a result of inflammation and fibrosis through cytokine secretion from the inflammatory cells and fibroblasts in the AM.

Academic Significance and Societal Importance of the Research Achievements

国内人口の高齢化が進み、動脈硬化症による脳血管障害性疾患は増加傾向にある。その背景には糖尿病や高血圧、血管壁の粥腫形成など近年慢性炎症と関連すると報告されている疾患が多くみうけられる。今回の研究では加齢に伴う動脈硬化などが背景となって、慢性炎症がくも膜の肥厚を引き起こしたと考えられた。慢性炎症、慢性虚血性変化を起こしている脳では認知機能低下がみられることから、これらの慢性炎症をベースとした生活習慣病の是正は今後の被介護人口の増加を抑制すべく重要な事項であると考えられた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2021 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Aging-associated inflammation and fibrosis in arachnoid membrane2021

    • Author(s)
      Suzuki Hime、Mikami Takeshi、Iwahara Naotoshi、Akiyama Yukinori、Wanibuchi Masahiko、Komatsu Katsuya、Yokoyama Rintaro、Hirano Tsukasa、Hosoda Ryusuke、Horio Yoshiyuki、Kuno Atsushi、Mikuni Nobuhiro
    • Journal Title

      BMC Neurology

      Volume: 21 Issue: 1 Pages: 169-178

    • DOI

      10.1186/s12883-021-02202-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] くも膜の線維化亢進と慢性炎症に影響する要因2018

    • Author(s)
      鈴木比女
    • Organizer
      第44回日本脳卒中学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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