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Novel internal radiotherapy for refractory malignant brain tumors

Research Project

Project/Area Number 18K16592
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionYokohama City University

Principal Investigator

Ohtake Makoto  横浜市立大学, 医学研究科, 客員研究員 (70644607)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsmalignant glioma / internal radiotherapy / Cu-ATSM / Brain tumor stem cells / glioma / stem like cells / 神経膠腫 / Cu-ATSM PET / グリオーマ幹細胞 / 神経膠芽腫 / 内部放射線療法 / 低酸素イメージング / 脳腫瘍幹細胞モデル
Outline of Final Research Achievements

Glioblastoma is one of the most lethal brain tumor. Although standard therapy, including surgery plus alkylating chemotherapy with radiothearpy, outcome remains unsatisfactory, thus novel therapeutic approach is crucial. Herein, we established novel internal radiotherapy for malignant gliomas, using 64Cu-ATSM. We confirmed survival benefit in Cu-ATSM treated patient derived brain tumor xenograft model.

Academic Significance and Societal Importance of the Research Achievements

悪性脳腫瘍において組織内低酸素状態は放射線治療や化学療法の耐性につながる問題を有する。これに対して
我々はこれまでに脳腫瘍の低酸素領域をCu-ATSM PETを用いて非侵襲的に同定することに成功してきた。今回の研究ではCu-ATSMを用いた内部放射線治療効果の意義を動物レベルで見出した。将来的にはCu-ATSMを用いて悪性脳腫瘍の治療抵抗領域を標的とした内部照射を行うという独創的な治療法を提唱することを目指す。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] Redox reaction and clinical outcome of primary diffuse large B-cell lymphoma of the central nervous system2020

    • Author(s)
      Tsuchiya Junichi、Yoneyama Tomohiro、Ohtake Makoto、Tateishi Kensuke、Bae Hyeyeol、Kishino Mitsuhiro、Tateishi Ukihide
    • Journal Title

      Nuclear Medicine Communications

      Volume: 41 Issue: 6 Pages: 567-574

    • DOI

      10.1097/mnm.0000000000001197

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor2018

    • Author(s)
      Umemura Masanari、Islam Md. Rafikul、Fukumura Hidenobu、Sato Itaru、Kawabata Yusuke、Matsuo Kousuke、Nakakaji Rina、Nagasako Akane、Ohtake Makoto、Takayuki Fujita、Yokoyama Utako、Nakayama Tomohiro、Eguchi Haruki、Ishikawa Yoshihiro
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 1 Pages: 356-365

    • DOI

      10.1111/cas.13851

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alternating magnetic field (AMF) enhances cytotoxicity of compound c.2018

    • Author(s)
      Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Eguchi H, Yamamoto T, Ishikawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 109 Issue: 11 Pages: 3483-3493

    • DOI

      10.1111/cas.13781

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 皮質脊髄路描出に影響を及ぼす因子解析と皮質MEP検出度の検証2019

    • Author(s)
      立石健祐 大竹誠 佐藤充 池谷直樹 末永潤 村田英俊 山本哲哉
    • Organizer
      第49回 日本臨床神経整理学会学術大会
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2021-02-19  

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