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Novel 3D image analysis to investigate the ossification of the posterior longitudinal ligament progression

Research Project

Project/Area Number 18K16612
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionNiigata University

Principal Investigator

Katsumi Keiichi  新潟大学, 医歯学総合病院, 特任准教授 (20422595)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords後縦靭帯骨化症 / 骨化進展 / 骨代謝動態 / 画像解析 / 頚椎 / 胸椎 / CT / CT / 3次元画像解析 / 骨代謝 / バイオマーカー / 骨化巣進展
Outline of Final Research Achievements

We assessed the ossification of the posterior longitudinal ligament (OPLL) progression using CT based three-dimensional (3D) image analysis and examined bone metabolism dynamics in 117 patients with OPLL (men, 72; women, 45; mean age, 63.7 years). The volume of OPLL was calculated twice during the follow-up period, and OPLL progression was evaluated by annual rate of ossification increase. Bone metabolism dynamics were assessed by routine blood sample and various serum biomarkers. Patients were classified into the progression (P group) and non-progression (NP group) groups according to the annual rate of increase in previous 3D image analyses.
Age, serum phosphorus, and serum sclerostin were identified as independent factors associated with the OPLL progression. Younger age, hypophosphatemia, and high serum sclerostin are risk factors for the OPLL progression. Serum phosphorus and sclerostin could serve as important biomarkers for predicting the ossification progression.

Academic Significance and Societal Importance of the Research Achievements

本研究では, 靭帯骨化症の進展と骨代謝動態を解析し, 骨化進展危険因子は若年と低リン血症と骨形成抑制蛋白である血清スクレロスチン高値が示唆された. 血清リンと血清スクレロスチンは共に骨代謝に深く関係する項目であり, 靭帯骨化症の進展メカニズムの解析の一助になる可能性がある. また血清リンと血清スクレロスチンは, 骨化進展を予測する重要なバイオマーカーとなる可能性があり, 臨床の様々な場面において患者の骨化進展速度予測に有用な可能性がある. 最後に, 抗スクレロスチン抗体製剤は, 現在重症骨粗鬆症治療薬として使用されており, 新規薬物治療法の確立が期待される.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2021 2020 2019 2018

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Impact of Ossification Expansion on Cervical Spine Function in Patients with Ossification of the Posterior Longitudinal Ligament: A Prospective Nationwide Multicenter Study (JOSL CT Study)2021

    • Author(s)
      勝見敬一, 平井高志, 吉井俊貴, 名越慈人, 西村空也, 森幹士,竹内一裕, 牧聡, 中村雅也, 松本守雄, 大川淳, 川口善治
    • Journal Title

      Journal of Spine Research

      Volume: 12 Issue: 9 Pages: 1087-1093

    • DOI

      10.34371/jspineres.2021-0043

    • NAID

      130008090553

    • ISSN
      1884-7137, 2435-1563
    • Year and Date
      2021-09-20
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progression Analysis of Ossification and Bone Metabolism in Patients with Cervical Ossification of the Posterior Longitudinal Ligament2021

    • Author(s)
      勝見敬一, 渡辺慶, 平野徹, 大橋正幸, 山崎昭義, 溝内龍樹, 石川裕也, 佐藤雅之, 和泉智博, 川島寛之
    • Journal Title

      Journal of Spine Research

      Volume: 12 Issue: 9 Pages: 1167-1173

    • DOI

      10.34371/jspineres.2021-0047

    • NAID

      130008090557

    • ISSN
      1884-7137, 2435-1563
    • Year and Date
      2021-09-20
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severity of Myelopathy is Closely Associated With Advanced Age and Signal Intensity Change in Cervical Ossification of the Posterior Longitudinal Ligament2021

    • Author(s)
      Hirai T., Yoshii T., Egawa S., Sakai K., Kusano K., Nakagawa Y., … Okawa A
    • Journal Title

      Clinical Spine Surgery: A Spine Publication

      Volume: Publish Ahead of Print Issue: 1 Pages: 1-11

    • DOI

      10.1097/bsd.0000000000001164

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The characteristics of the young patients with cervical ossification of the posterior longitudinal ligament of the spine: a multicenter prospective cross-sectional study2021

    • Author(s)
      Mori K, Yoshii T, Hirai T, Maki S, Katsumi K, et al.
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: in press Issue: 4 Pages: 760-766

    • DOI

      10.1016/j.jos.2021.04.010

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament2021

    • Author(s)
      Katsumi K, Hirai T, Yoshii T, Maki S, Mori K, Nagoshi N, Nishimura S, et al.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 14337-14337

    • DOI

      10.1038/s41598-021-93602-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics in patients with ossification of the posterior longitudinal ligament: A prospective multi-institutional cross-sectional study2020

    • Author(s)
      Hirai T., Yoshii T., Ushio S., Mori K., Maki S., Katsumi K.,…Kawaguchi Y.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-020-62278-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study2020

    • Author(s)
      Hirai T., Yoshii T., Ushio S., Hashimoto J., Mori K, Maki S.,… Kawaguchi Y.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 12 Pages: 4055-4055

    • DOI

      10.3390/jcm9124055

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 頚椎後縦靭帯骨化症の骨化進展因子と予測バイオマーカーの確立2021

    • Author(s)
      勝見敬一, 渡辺慶, 平野徹, 渡辺慶, 和泉智博, 山崎昭義, 溝内龍樹, 石川裕也, 佐藤雅之, 坂本徹夫, 川島寛之
    • Organizer
      第31回 東北脊椎外科研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 頚椎後縦靭帯骨化症の骨化進展因子と予測バイオマーカーの確立2021

    • Author(s)
      勝見敬一
    • Organizer
      第31回 東北脊椎外科研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頚椎後縦靭帯骨化症の骨化進展と骨代謝動態の解析2020

    • Author(s)
      勝見敬一
    • Organizer
      第48回 日本脊椎脊髄病学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頚椎後縦靭帯骨化症の骨化進展と骨代謝動態の解析2020

    • Author(s)
      勝見敬一
    • Organizer
      第49回 日本脊椎脊髄病学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 骨化巣の3 次元画像解析と 全脊柱CT 研究による骨化進展と頚椎機能解析2019

    • Author(s)
      勝見敬一
    • Organizer
      厚生労働省科学研究費補助金難治性疾患等政策研究事業 【脊柱靭帯骨化症に関する調査研究】 令和元年度第2回合同班会議
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 脊柱縦靭帯骨化症の骨化進展と骨代謝動態の解析2018

    • Author(s)
      勝見敬一
    • Organizer
      厚生労働省科学研究費補助金難治性疾患等政策研究事業 【脊柱靭帯骨化症に関する調査研究】平成30年度第2回合同班会議
    • Related Report
      2018 Research-status Report
  • [Book] OPLL Ossification of the Posterior Longitudinal Ligament: Third edition2020

    • Author(s)
      Katsumi K, Hirano T, Watanabe K, Izumi T, Ohashi M, Mizouchi T, Endo N
    • Total Pages
      278
    • Publisher
      Springer
    • ISBN
      9789811538544
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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