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A hand OA-specific cohort from Okumikawa medical valley project

Research Project

Project/Area Number 18K16620
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionNagoya University

Principal Investigator

Nakagawa Yasunobu  名古屋大学, 医学系研究科, 招へい教員 (30801633)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords手指変形性関節症 / コホート / 奥三河メディカルバレープロジェクト / システマティック・レビュー / メタアナリシス / 手指機能障害 / FIHOA / スクリーニング / hand OA / 奥三河プロジェクト / Hand OA / 新城市 / 関節症 / 奥三河 / Biobank / ロコモティブシンドローム / 横断研究
Outline of Final Research Achievements

I made a Japanese version of the Functional Index for Hand Osteoarthritis (J-FIHOA), which is a leading assessment patient reported measurement questionnaire for hand OA-related functional impairment. We validated it among approximately 200 Japanese hand OA patients.
We have corroborated with Shinshiro city and run Okumikawa medical valley project. Hand OA is one of major target diseases of the projects and we started recruiting the patients using the FIHOA. We faced difficulty in the patient recruitment because of the Covid-19 pandemic, I performed systematic review and meta-analysis to assess how patient characteristics and study design influence the effectiveness of control interventions in hand OA trials. It was published in a high impact journal and will help conducting future trials.

Academic Significance and Societal Importance of the Research Achievements

Hand OAはその有病率の高さと、手指機能・美容面に与える影響が大きい一方で、確たる治療法が無いことからforgetten diseaseとされている。我々の作成した日本語版FIHOAは、手指の機能障害を簡便に評価できる指標であり、広くhand OA患者に用いられることとなった。これにより、有症状の患者を一般人口のレベルでスクリーニングすることが可能となり、コホート作成の段階へと研究が進むこととなった。患者登録が困難な時期に実施したシステマティック・レビューは、今後期待される介入試験の研究デザイン構築に寄与することが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] Saint-Antoine Hospital, AP-HP(フランス)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Choice of control group treatments in hand osteoarthritis trials: a systematic review and meta-analysis2021

    • Author(s)
      Nakagawa Yasunobu、Tatebe Masahiro、Yamamoto Michiro、Kurimoto Shigeru、Iwatsuki Katsuyuki、Hirata Hitoshi
    • Journal Title

      Seminars in Arthritis and Rheumatism

      Volume: 51 Issue: 4 Pages: 775-785

    • DOI

      10.1016/j.semarthrit.2021.04.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 手指変形性関節症患者に用いる日本語版Functional Index for Hand Osteoarthritis(J-FIHOA)に対するラッシュ分析2021

    • Author(s)
      中川 泰伸, 岩月 克之, 栗本 秀, 山本 美知郎, 建部 将広, 平田 仁
    • Journal Title

      日本手外科学会雑誌

      Volume: 37

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-cultural translation, adaptation and validation of a Japanese version of the functional index for hand osteoarthritis (J-FIHOA)2020

    • Author(s)
      Nakagawa Yasunobu、Kurimoto Shigeru、Maheu Emmanuel、Matsui Yuichiro、Kanno Yuri、Menuki Kunitaka、Hayashi Masanori、Nemoto Tetsuya、Nishizuka Takanobu、Tatebe Masahiro、Yamamoto Michiro、Iwatsuki Katsuyuki、Renee Liliane Dreiser、Hirata Hitoshi
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 21 Issue: 1 Pages: 173-173

    • DOI

      10.1186/s12891-020-03193-6

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 特集 これで完璧! 手の変形性関節症-最新のエビデンスから紐解く- 3.診断 手の変形性関節症に対する診断・評価ツール2018

    • Author(s)
      中川 泰伸, 平田 仁, 建部 将広, 山本 美知郎, 栗本 秀, 新海 宏明
    • Journal Title

      整形・災害外科

      Volume: 61 Issue: 5 Pages: 517-522

    • DOI

      10.18888/se.0000000442

    • ISSN
      0387-4095
    • Year and Date
      2018-04-30
    • Related Report
      2018 Research-status Report
  • [Journal Article] 特集 これで完璧! 手の変形性関節症-最新のエビデンスから紐解く- 6.治療 手の変形性関節症に対する薬物療法2018

    • Author(s)
      中川 泰伸, 平田 仁, 建部 将広, 山本 美知郎, 栗本 秀, 新海 宏明
    • Journal Title

      整形・災害外科

      Volume: 61 Issue: 5 Pages: 577-580

    • DOI

      10.18888/se.0000000451

    • ISSN
      0387-4095
    • Year and Date
      2018-04-30
    • Related Report
      2018 Research-status Report
  • [Presentation] 手指変形性関節症患者に用いる日本語版Functional Index for Hand Osteoarthritis (J-FIHOA)に対するラッシュ分析2020

    • Author(s)
      中川泰伸
    • Organizer
      第63回日本手外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 手指変形性関節症に用いる患者立脚型評価票Functional Index for Hand Osteoarthritisの日本語版作成及び妥当性の検証(続報)2019

    • Author(s)
      中川泰伸
    • Organizer
      第62回日本手外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 手指の変形性関節症に対する保存療法2019

    • Author(s)
      中川泰伸
    • Organizer
      第92回日本整形外科学会学術総会
    • Related Report
      2019 Research-status Report 2018 Research-status Report
  • [Presentation] Cross-cultural Translation, Adaptation and Validation of a Japanese Version of the Functional Index for Hand OsteoArthritis (J-FIHOA)2019

    • Author(s)
      Yasunobu Nakagawa
    • Organizer
      OARSI 2019 (Osteoarthritis Research Society International)、Toronto
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cross-cultural Translation, Adaptation and Validation of a Japanese Version of the Functional Index for Hand OsteoArthritis (J-FIHOA)2019

    • Author(s)
      Yasunobu Nakagawa
    • Organizer
      EULAR 2019 (Annual European Congress of Rheumatology)、Madrid
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 手指変形性関節症に用いる患者立脚型評価票Functional Index for Hand Osteoarthritisの日本語版作成及び妥当性の検証(続報)2019

    • Author(s)
      中川泰伸
    • Organizer
      第62回日本手外科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Cross-cultural Translation, Adaptation and Validation of a Japanese Version of the Functional Index for Hand OsteoArthritis (J-FIHOA)2019

    • Author(s)
      Yasunobu Nakagawa
    • Organizer
      OARSI 2019 (Osteoarthritis Research Society International)
    • Related Report
      2018 Research-status Report
  • [Presentation] Cross-cultural Translation, Adaptation and Validation of a Japanese Version of the Functional Index for Hand OsteoArthritis (J-FIHOA)2019

    • Author(s)
      Yasunobu Nakagawa
    • Organizer
      EULAR 2019 (Annual European Congress of Rheumatology)
    • Related Report
      2018 Research-status Report
  • [Presentation] 手指変形性関節症に用いる患者立脚型評価票Functional Index for Hand Osteoarthritisの日本語版作成及び妥当性の検証2018

    • Author(s)
      中川泰伸
    • Organizer
      第61回日本手外科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Book] 整形外科診療のためのガイドライン活用術2019

    • Author(s)
      大川 淳、平田 仁
    • Total Pages
      240
    • Publisher
      中山書店
    • ISBN
      9784521747743
    • Related Report
      2019 Research-status Report
  • [Book] TEXT整形外科学2019

    • Author(s)
      大鳥精司、高相晶士、出家正隆、吉矢晋一
    • Total Pages
      484
    • Publisher
      南山堂
    • ISBN
      9784525320553
    • Related Report
      2019 Research-status Report
  • [Remarks] 奥三河メディカルバレープロジェクト

    • URL

      http://omv.aichi.jp/index.php

    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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