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Intraoperative spinal cord monitoring waveform analysis and formulation of new alarm points for postoperative paralysis prevention

Research Project

Project/Area Number 18K16621
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionNagoya University

Principal Investigator

Kobayashi Kazuyoshi  名古屋大学, 医学部附属病院, 病院講師 (00706294)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脊椎手術 / 脊髄モニタリング / 多施設前向き研究 / 脊髄損傷 / 脊髄手術
Outline of Final Research Achievements

Tc-MEPs are widely used for IONM, but some cases have poor waveform derivation, even in multichannel Tc-MEP monitoring. The subjects were 3,625 patients who underwent Tc-MEP monitoring during spinal surgery at 16 spine centers between April 2017 and March 2020. Baseline Tc-MEPs were recorded from the deltoid, abductor pollicis brevis, adductor longus, quadriceps femoris, hamstrings, tibialis anterior, gastrocnemius, and abductor hallucis (AH) muscles after surgical exposure of the spine. The 3,625 cases included cervical, thoracic, and lumbar lesions (50%, 33% and 17%, respectively) and had preoperative motor status of no motor deficit, and motor deficit with MMT ≧3 and MMT <3. High-risk surgery was performed in 1,540 cases (43%). There were 73 cases with poor baseline waveform derivation (2%), and this was significantly associated with higher body weight, body mass index, thoracic lesions, motor deficit of MMT <3, high-risk surgery, and surgery for OPLL.

Academic Significance and Societal Importance of the Research Achievements

脊椎・脊髄手術は、危険な局面での手術が要求されることが多く、術中に生じる麻痺発生率も約2%と報告されている。一旦脊髄が損傷されるとその回復は極めて難しく、術後患者に与える肉体的、精神的、経済的負担は極めて大きい。故に、術中に脊髄損傷を未然に防ぐ安全な処置が望まれる。本研究成果の学術意義として、術中に波形が変化する中で、どのタイミングで手術の進行を止めるのかのアラームポイントが未だ一定ではないことであった。Tc-MEPにおける波形悪化の詳細な検討とアラームポイント策定は、臨床現場での予期せぬ術後麻痺を一例でも多く減らせうる一助になりうる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results) Presentation (8 results) Book (1 results)

  • [Journal Article] Poor derivation of Tc-MEP baseline waveforms in surgery for ventral thoracic intradural extramedullary tumor: Efficacy of use of the abductor hallucis in cases with a preoperative non-ambulatory status2021

    • Author(s)
      Kazuyoshi Kobayashi, Kei Ando, Hiroaki Nakashima, Masaaki Machino, Shunsuke Kanbara, Sadayuki Ito, Taro Inoue, Hiroyuki Koshimizu, Hidetoshi Yamaguchi, Shiro Imagama
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 84 Pages: 60-65

    • DOI

      10.1016/j.jocn.2020.11.045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of cases with poor Tc-MEP baseline waveform derivation in spine surgery: A prospective multicenter study of the Monitoring Committee of the Japanese Society for Spine Surgery and Related Research2021

    • Author(s)
      Kobayashi K, Imagama S, Ando K, Yoshida G, Ando M, Kawabata S, Yamada K, Kanchiku T, Fujiwara Y, Taniguchi S, Iwasaki H, Shigematsu H, Tadokoro N, Takahashi M, Wada K, Yamamoto N, Funaba M, Yasuda A, Ushirozako H, Hashimoto J, Morito S, Takatani N, Tani T, Matsuyama Y
    • Journal Title

      SPINE

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Intraoperative Intervention Following Transcranial Motor-evoked Potentials Alert During Posterior Decompression and Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study of the Monitoring Committee of the Japanese Society for Spine Surgery and Related Research2021

    • Author(s)
      Kobayashi K, Imagama S, Yoshida G, Ando M, Kawabata S, Yamada K, Kanchiku T, Fujiwara Y, Taniguchi S, Iwasaki H, Tadokoro N, Takahashi M, Wada K, Yamamoto N, Shigematsu H, Funaba M, Yasuda A, Ushirozako H, Tani T, Matsuyama Y.
    • Journal Title

      SPINE

      Volume: 46 Issue: 4 Pages: 268-276

    • DOI

      10.1097/brs.0000000000003774

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal stimulation intensity for Br(E)-MsEP waveform derivation at baseline in pediatric spinal surgery.2019

    • Author(s)
      Kobayashi K, Ando K, Machino M, Ota K, Morozumi M, Tanaka S, Kanbara S, Ito S, Ishiguro N, Imagama S
    • Journal Title

      Clin Neurol Neurosurg.

      Volume: 180 Pages: 74-78

    • DOI

      10.1016/j.clineuro.2019.03.005

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characteristics of multi-channel Br(E)-MsEP waveforms for the lower extremity muscles in thoracic spine surgery: comparison based on preoperative motor status.2019

    • Author(s)
      Kobayashi K, Ando K, Tsushima M, Machino M, Ota K, Morozumi M, Tanaka S, Kanbara S, Ishiguro N, Imagama S
    • Journal Title

      Eur Spine J.

      Volume: 28 Issue: 3 Pages: 484-491

    • DOI

      10.1007/s00586-018-5825-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Wave changes in intraoperative transcranial motor-evoked potentials during posterior decompression and dekyphotic corrective fusion with instrumentation for thoracic ossification of the posterior longitudinal ligament.2019

    • Author(s)
      Ando K, Kobayashi K, Machino M, Ota K, Morozumi M, Tanaka S, Ishiguro N, Imagama S
    • Journal Title

      Eur J Orthop Surg Traumatol

      Volume: 29 Issue: 6 Pages: 1177-1185

    • DOI

      10.1007/s00590-019-02435-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Wave Change of Intraoperative Transcranial Motor-Evoked Potentials During Corrective Fusion for Syndromic and Neuromuscular Scoliosis.2019

    • Author(s)
      Ando K, Kobayashi K, Ito K, Tsushima M, Morozumi M, Tanaka S, Machino M, Ota K, Nishida Y, Ishiguro N, Imagama S
    • Journal Title

      Oper Neurosurg

      Volume: 16 Issue: 1 Pages: 53-58

    • DOI

      10.1093/ons/opy045

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of a Combination of Waveform Amplitude and Peak Latency in Intraoperative Spinal Cord Monitoring2018

    • Author(s)
      Kobayashi Kazuyoshi、Ando Kei、Shinjo Ryuichi、Ito Kenyu、Tsushima Mikito、Morozumi Masayoshi、Tanaka Satoshi、Machino Masaaki、Ota Kyotaro、Ishiguro Naoki、Imagama Shiro
    • Journal Title

      SPINE

      Volume: 43 Issue: 17 Pages: 1231-1237

    • DOI

      10.1097/brs.0000000000002579

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new criterion for the alarm point using a combination of waveform amplitude and onset latency in Br(E)-MsEP monitoring in spine surgery2018

    • Author(s)
      Kobayashi Kazuyoshi、Ando Kei、Shinjo Ryuichi、Ito Kenyu、Tsushima Mikito、Morozumi Masayoshi、Tanaka Satoshi、Machino Masaaki、Ota Kyotaro、Ishiguro Naoki、Imagama Shiro
    • Journal Title

      Journal of Neurosurgery: Spine

      Volume: 29 Issue: 4 Pages: 435-441

    • DOI

      10.3171/2018.3.spine171348

    • NAID

      40022077176

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Anal Needle Electrodes for Intraoperative Spinal Cord Monitoring with Transcranial Muscle Action Potentials2018

    • Author(s)
      Kobayashi Kazuyoshi、Ando Kei、Yagi Hideki、Ito Kenyu、Tsushima Mikito、Morozumi Masayoshi、Tanaka Satoshi、Machino Masaaki、Ota Kyotaro、Matsuyama Yukihiro、Ishiguro Naoki、Imagama Shiro
    • Journal Title

      Asian Spine Journal

      Volume: 12 Issue: 4 Pages: 662-668

    • DOI

      10.31616/asj.2018.12.4.662

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 高リスク脊椎手術におけるTc-MEPs波形導出不良例の検討2020

    • Author(s)
      小林 和克, 今釜 史郎, 吉田 剛, 安藤 宗治, 谷口 愼一郎, 岩崎 博, 川端 茂徳, 山田 圭, 藤原 靖, 和田 簡一郎, 松山 幸弘
    • Organizer
      第49回 日本脊椎脊髄病学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胸髄腫瘍における腫瘍局在からみたBr(E)-MsEP波形の特性2020

    • Author(s)
      小林 和克, 今釜 史郎, 安藤 圭, 中島 宏彰, 町野 正明, 両角 正義, 神原 俊輔, 伊藤 定之, 井上 太郎, 山口 英敏, 小清水 宏行, 石黒 直樹
    • Organizer
      第49回 日本脊椎脊髄病学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胸椎手術における術前麻痺と脊髄モニタリング波形導出率 下肢筋毎に分けた検討2020

    • Author(s)
      小林 和克, 今釜 史郎, 安藤 圭, 町野 正明, 大田 恭太郎, 田中 智史, 両角 正義, 神原 俊輔, 伊藤 定之, 石黒 直樹
    • Organizer
      第41回 脊髄機能診断研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胸椎手術における術前motor statusからみた波形導出率の検討2019

    • Author(s)
      小林 和克, 今釜 史郎, 安藤 圭, 町野 正明, 田中 智史, 両角 正義, 神原 俊輔, 伊藤 定之, 井上 太郎, 石黒 直樹
    • Organizer
      第49回日本臨床神経生理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 胸椎手術における術前麻痺と脊髄モニタリング波形導出率-下肢筋毎に分けた検討-2019

    • Author(s)
      小林 和克, 今釜 史郎, 安藤 圭, 町野 正明, 田中 智史, 両角 正義, 神原 俊輔, 伊藤 定之, 井上 太郎, 石黒 直樹
    • Organizer
      第40回脊髄機能診断研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 小児脊椎手術におけるTc-MsEP刺激強度の検討2018

    • Author(s)
      小林和克、今釜史郎、安藤圭、伊藤研悠、都島幹人、両角正義、田中智史、町野正明、大田恭太郎、西田佳弘、石黒直樹
    • Organizer
      脊髄機能診断研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胸椎OPLL手術における術中脊髄モニタリング波形悪化因子の検討 2018日本脊椎脊髄病学会脊髄モニタリングワーキンググループ多施設前向き研究2018

    • Author(s)
      小林 和克, 今釜 史郎, 松山 幸弘, 安藤 宗治, 山田 圭, 吉田 剛, 小林 祥, 川端 茂徳, 高橋 雅人, 藤原 靖, 田所 伸朗, 和田 簡一郎, 寒竹 司, 山本 直也, 谷 俊一
    • Organizer
      日本脊椎脊髄病学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胸椎手術における術前麻痺と脊髄モニタリング波形導出率 下肢筋ごとの検討2018

    • Author(s)
      小林 和克, 今釜 史郎, 安藤 圭, 伊藤 研悠, 都島 幹人, 両角 正義, 田中 智史, 町野 正明, 大田 恭太郎, 西田 佳弘, 石黒 直樹
    • Organizer
      日本整形外科学会
    • Related Report
      2018 Research-status Report
  • [Book] 【脊椎脊髄外科の最近の進歩】各種疾患に対する治療法・モダリティ 術中脊髄機能モニタリング(解説/特集):整形・災害外科2019

    • Author(s)
      小林 和克(名古屋大学 大学院医学系研究科運動・形態外科学), 今釜 史郎, 安藤 圭, 石黒 直樹
    • Publisher
      金原出版
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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