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Development of glycobiomarker for prediction of castration prostate cancer

Research Project

Project/Area Number 18K16681
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56030:Urology-related
Research InstitutionHirosaki University

Principal Investigator

Ishibashi Yusuke  弘前大学, 医学研究科, 客員研究員 (80792316)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsイムノグロブリン / 前立腺癌 / N型糖鎖 / 去勢抵抗性 / リキッドバイオプシー / 糖転移酵素 / CRPC / 糖鎖
Outline of Final Research Achievements

Androgen deprivation therapy (ADT) is effective in the treatment of hormone-sensitive prostate cancer (HSPC), but the prognosis for patients who develop resistance to ADT and progress to castration-resistant prostate cancer (CRPC) is poor. However, there are no predictive markers that can predict the acquisition of castration resistance and provide useful information for treatment decisions. In this study, we constructed a diagnostic model to differentiate HSPC and CRPC using an immunoglobulin N-glycan signature and a machine learning model. The constructed diagnostic model diagnoses CRPC with an AUC of 0.88 or higher and is expected to be useful in predicting CRPC in the future.

Academic Significance and Societal Importance of the Research Achievements

PSAによる前立腺癌のスクリーニングにより、早期の前立腺癌が発見され、治療の対象になっている現状では、前立腺癌をコントロールする上でHSPCの治療効果やCRPCの予測に本手法を導入し、早期に適切な治療介入を行うことは患者のQOL向上および医療費軽減につながり、これらは、今後、個別化医療が進むにつれ、より一層重要な検査となると考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Serum N-glycan profiling is a potential biomarker for castration-resistant prostate cancer2019

    • Author(s)
      Matsumoto Teppei、Hatakeyama Shingo、Yoneyama Tohru、Tobisawa Yuki、Ishibashi Yusuke、Yamamoto Hayato、Yoneyama Takahiro、Hashimoto Yasuhiro、Ito Hiroyuki、Nishimura Shin-Ichiro、Ohyama Chikara
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 16761-16761

    • DOI

      10.1038/s41598-019-53384-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 泌尿器腫瘍に対する分子マーカーの研究の現状と将来 泌尿器腫瘍に対する糖鎖バイオマーカーの現状と将来2018

    • Author(s)
      米山徹、石川友一、金子智典、彼谷高敏、飛澤悠葵、畠山真吾、田中壽一、石橋祐介、萩原和久、橋本安弘、古家琢也、伊達睦廣、須田美彦、大山力
    • Organizer
      第56回日本癌治療学会
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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