Organ Preservation Targeted Therapy of Prostate Cancer Based on Localization Diagnosis by Real-Time Imaging

• Project/Area Number: 18K16704
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Nagoya City University
• Principal Investigator: Nagai Takashi 名古屋市立大学, 医薬学総合研究院(医学), 臨床研究医 (20813447)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 前立腺癌 / 局所療法 / 局在診断 / 局所治療 / ナノ粒子 / MRI / 局所標的治療

Outline of Final Research Achievements

In this study, we attempted to establish accurate imaging and puncture techniques for organ-preservation therapy of prostate cancer, and analyzed the test results for the application of MRI-TRUS prostate biopsy, which combines MRI imaging and transrectal ultrasound (TRUS). We also analyzed the test results of surveillance therapy in prostate biopsy to verify the reproducibility and accuracy of the puncture technique. In addition, we conducted basic experiments of hyperthermia using iron oxide containing nanoparticles.

Academic Significance and Societal Importance of the Research Achievements

本研究では、臨床データの解析から、MRI-TRUS前立腺生検は再現性があり、正確な穿刺技術に応用可能であることがわかった。これらの結果からMRI-TRUS前立腺生検の穿刺技術は局在診断から局所注入まで高い精度で行うことが期待される。さらに本研究で検証したMRI-TRUS前立腺生検の穿刺技術を用いることで、前立腺癌局所注入療法による温熱療法への応用が期待できる。そして前立腺癌患者における治療選択肢の一つとしての前立腺癌局所注入温熱療法確立の基盤になるといえる。

Research Products

• [Journal Article] MRI-guided prostate needle biopsy using a BioJet navigation system is useful for precise prostate cancer localization (2020)
  • Author(s): Nagai Takashi, Naiki Taku, Hamamoto Shuzo, Etani Toshiki, Iwatsuki Shoichiro, Niki Aya, Nakagawa Motoo, Kawai Tatsuya, Taguchi Kazumi, Iida Keitaro, Noda Yusuke, Kawase Kengo, Okada Tomoki, Shimizu Nobuhiko, Matsuyama Nayuka, Hattori Tatsuya, Chaya Ryosuke, Kato Taiki, Kawai Noriyasu, Yasui Takahiro
  • Journal Title: Japanese Journal of Endourology Volume: 33 Issue: 2 Pages: 307-311
  • DOI: 10.11302/jsejje.33.307
  • NAID: 130007949089
  • ISSN: 2186-1889, 2187-4700
  • Peer Reviewed
• [Journal Article] Comparison of real-time virtual sonography navigation versus BioJet navigation on magnetic resonance imaging guided prostate needle biopsy: a single institutional analysis (2020)
  • Author(s): Takashi Nagai, Taku Naiki, Shuzo Hamamoto, Toshiki Etani, Aya Naiki-Ito, Motoo Nakagawa, Keitaro Iida, Shoichiro Iwatsuki, Kazumi Taguchi, Tetsuji Maruyama, Noriyasu Kawai, Satoru Takahashi, Takahiro Yasui
  • Journal Title: Journal of Endourology Volume: オンライン Issue: 7 Pages: 739-745
  • DOI: 10.1089/end.2020.0042
  • Peer Reviewed
• [Journal Article] Examination of diagnostic accuracy of urovysion fluorescence in situ hybridization for bladder cancer in a single community of Japanese hospital patient (2019)
  • Author(s): Nagai T, Okamura T, Yanase T, Chaya R, Kobayashi D, Akita H, Moritoki Y, Yasui T
  • Journal Title: Asian Pac J Cancer Prev. Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Early abiraterone acetate treatment is beneficial in Japanese castration-resistant prostate cancer after failure of primary combined androgen blockade. (2018)
  • Author(s): Nagai T, Naiki T (corresponding), Iida K, Etani T, Ando R, Hamamoto S, Sugiyama Y, Akita H, Kubota H, Hashimoto Y, Kawai N, Yasui T.
  • Journal Title: Prostate Int Volume: 1 Issue: 1 Pages: 18-23
  • DOI: 10.1016/j.prnil.2017.07.001
  • Peer Reviewed / Open Access
• [Presentation] MRI-TRUS 融合前立腺生検を用いた監視療法の成績 (2020)
  • Author(s): 永井 隆、内木 拓、濱本 周造、丸山 哲史、惠谷 俊紀、河合 憲康、安井 孝周
  • Organizer: 第58回癌治療学会学術集会
• [Presentation] 当院におけるBiojetシステムを用いたMRI同期下前立腺針生検による癌局在診断 (2020)
  • Author(s): 内木 拓、永井 隆、濵本 周造、飯田 啓太郎、惠谷 俊紀、野田 祐介、清水 伸彦、安藤 亮介、河合 憲康、安井 孝周
  • Organizer: 第58回癌治療学会学術集会
• [Presentation] BiojetシステムおよびRealtime Virtual Sonographyガイド下MRI-TRUS融合前立腺生検の癌検出率の検討 (2019)
  • Author(s): 永井 隆、内木 拓、濵本 周造、飯田 啓太郎、惠谷 俊紀、安藤 亮介、丸山 哲史、河合 憲康、小林 大地、秋田 英俊、岡村 武彦、安井 孝周
  • Organizer: 第107回日本泌尿器科学会総会
• [Presentation] Comparing real-time virtual sonography system and biojet fusion system biopsy to transperineal MRI-TRUS fusion prostate biopsy (2019)
  • Author(s): Nagai Takashi, Naiki Taku, Hamamoto Shuzo, Iida Keitaro, Ando Ryosuke, Etani Toshiki, Kawai Noriyasu, Chaya Ryosuke, Moritoki Yoshinobu, Kobayashi Daichi, Akita Hidetoshi, Okamura Takehiko, Taguchi Kazumi, Maruyama Tetsuji, Yasui Takahiro
  • Organizer: 17th Urological Association of Asia Congress
  • Int'l Joint Research
• [Presentation] ゲムシタビン内包型マグネタイト結合単層カーボナノホーンを用いた磁場照射による尿路上皮癌に対する温熱化学療法の開発 (2019)
  • Author(s): 河合 憲康、堤内 要、今栄 東洋子、野崎 哲史、飯田 啓太郎、惠谷 俊紀、内木 拓、安藤 亮介、安井 孝周
  • Organizer: 日本ハイパーサーミア学会第36回大会
• [Presentation] BioJet生検はRVS生検よりも前立腺移行域において癌検出率が高い (2019)
  • Author(s): 永井 隆、内木 拓、濵本 周造、茶谷 亮輔、飯田 啓太郎、守時 良演、惠谷 俊紀、田口 和己、小林 大地、安藤 亮介、秋田 英俊、岡村 武彦、河合 憲康、丸山 哲史、安井 孝周
  • Organizer: 第57回日本癌治療学会学術集会