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Elucidation of castration-resistant prostate cancer mechanism via hedgehog pathway

Research Project

Project/Area Number 18K16716
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56030:Urology-related
Research InstitutionOsaka Medical College

Principal Investigator

Ibuki Naokazu  大阪医科大学, 医学部, 講師 (90368100)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords去勢抵抗性前立腺癌 / Enzalutamide / Hedgehog / Hedgehog pathway
Outline of Final Research Achievements

Pharmacotherapy for castration-resistant prostate cancer has been developing in recent years with the advent of new drugs. However, the drug will eventually become ineffective and new drugs are expected to appear.
Our study suggests that the Hedgehog pathway may be involved in Enzalutamide resistance, one of the drug therapies for castration-resistant prostate cancer, and will lead to the development of new drugs for castration-resistant prostate cancer. It was considered.

Academic Significance and Societal Importance of the Research Achievements

去勢抵抗性前立腺癌のメカニズムおよび去勢抵抗性前立腺癌に対する薬物療法(Enzalutamide)抵抗性のメカニズムを検討するため、癌細胞を用いてHedgehog経路が関与しているかどうかの実験を行った。
結果、Hedgehog経路を抑制することで去勢抵抗性前立腺癌およびEnzalutamide抵抗性前立腺癌に対して治療効果が発揮されることを確認した。今後の新薬開発につながるものと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2019 2018

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Comparison of Radiographic Progression-Free Survival and PSA Response on Sequential Treatment Using Abiraterone and Enzalutamide for Newly Diagnosed Castration-Resistant Prostate Cancer: A Propensity Score Matched Analysis from Multicenter Cohort.2019

    • Author(s)
      Komura K,Fujiwara Y,UchimotoT,Saito K,Tanda N,Matsunaga T, Ichihashi A,Tsutsumi T, Tsujino T,Yoshikawa Y,Nishimoto Y,Takai T,Minami K,Taniguchi K,Tanaka T, Uehara H,Hirano H,Nomi H,Ibuki N, Takahara K,Inamoto T,Azuma H.
    • Journal Title

      J. Clin. Med.

      Volume: 8(8) Issue: 8 Pages: 1251-1251

    • DOI

      10.3390/jcm8081251

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan.2019

    • Author(s)
      Komura K,Hashimoto T, Tsujino T, Muraoka R, Tsutsumi T, Satake N, Matsunaga T, Yoshikawa Y, Takai T, Minami K, Taniguchi K, Uehara H, Tanaka T, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Ohno Y, Azuma H.
    • Journal Title

      Ann Surg Oncol.

      Volume: 26(9) Issue: 9 Pages: 2994-3004

    • DOI

      10.1245/s10434-019-07530-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder2018

    • Author(s)
      Inamoto Teruo、Uehara Hirofumi、Akao Yukihiro、Ibuki Naokazu、Komura Kazumasa、Takahara Kiyoshi、Takai Tomoaki、Uchimoto Taizo、Saito Kenkichi、Tanda Naoki、Yoshikawa Yuki、Minami Koichiro、Hirano Hajime、Nomi Hayahito、Kato Ryuji、Hayashi Tetsuya、Azuma Haruhito
    • Journal Title

      Disease Markers

      Volume: 2018 Pages: 1-6

    • DOI

      10.1155/2018/5468672

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] hibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D.2018

    • Author(s)
      Komura K、Yoshikawa Y, Shimamura T, Chakraborty G, Gerke TA, Hinohara K, Chadalavada K, Jeong SH, Armenia J, Du SY, Mazzu YZ, Taniguchi K, Ibuki N, Meyer CA, Nanjangud GJ, Inamoto T, Lee GM, Mucci LA, Azuma H, Sweeney CJ, Kantoff PW.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128(7) Issue: 7 Pages: 2979-95

    • DOI

      10.1172/jci96769

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Treatment outcome of dose reduction of enzalutamide against CRPC?2019

    • Author(s)
      Ibuki N, Inamoto T,Ichihashi A,Uehara H,Komura K,Hirano H,Nomi H,Azma H.
    • Organizer
      AUA 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] プラチナ抵抗性尿路上皮癌に対するPembrolizumabの治療効果予測因子の検討2019

    • Author(s)
      伊夫貴 直和、稲元輝生、内本泰三、辻野拓也、南 幸一郎、光野絢子、高木 志寿子、木下将宏、徳永雄希、土井 由紀子、中森啓太、木山 賢、東 治人.
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 当施設における腎細胞癌に対するpresurgical therapyの臨床的検討2019

    • Author(s)
      伊夫貴 直和、稲元輝生、小村和正、上原博史、平野 一、能見勇人、東 治人.
    • Organizer
      日本泌尿器腫瘍学会 第5回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ハイリスクホルモン感受性転移性前立腺癌に対するAbiraterone acetateとPrednisolone併用療法の治療効果2019

    • Author(s)
      伊夫貴 直和、稲元輝生、西本優大、内本泰三、光野絢子、藤川正弘、土井 亘、宮下 由紀恵、木村亮輔、小山耕平、木山 賢、和辻利和、東 治人.
    • Organizer
      第69回日本泌尿器科学会中部総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 生体腎移植前のドナー検査において腫瘍性病変が指摘され、根治的治療が可能であった3症例2019

    • Author(s)
      上原博史、平野 一、岡部知太、木村孝平、寺本昌司、高倉一平、西村一希、木下将宏、徳永雄希、中森啓太、市橋 淳、谷口俊理、小林大介、堤 岳之、小村和正、伊夫貴 直和、稲元輝生、能見勇人、東 治人.
    • Organizer
      第53回日本臨床腎移植学会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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