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Influence of chronic inflammation on lower urinary tract symptoms in rats with life-style related disease

Research Project

Project/Area Number 18K16729
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56030:Urology-related
Research InstitutionUniversity of Fukui

Principal Investigator

Seki Masaya  福井大学, 学術研究院医学系部門, 助教 (70572444)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords糖尿病 / 下部尿路機能 / 炎症性サイトカイン / 膀胱血流 / 前立腺血流 / 2型糖尿病 / 蓄尿障害 / tadalafil / 膀胱血流障害 / ATP / 生活習慣病 / 下部尿路症状 / 炎症 / 血管拡張 / 前立腺 / 膀胱 / 心理ストレス / CRF / 排尿
Outline of Final Research Achievements

An increase in prostate weight was observed in the type 2 diabetes model, suggesting that inflammatory cytokines may act as growth factors. PDE-5 inhibitors are thought to decrease pro-inflammatory cytokines in the prostate and to suppress prostate enlargement.
An increase in voiding frequency and storage dysfunction were observed in the type 2 diabetes model, suggesting that inflammatory cytokines may induce storage dysfunction. PDE-5 inhibitors are thought to decrease pro-inflammatory cytokines in the bladder and to improve the storage dysfunction.

Academic Significance and Societal Importance of the Research Achievements

2型糖尿病などの生活習慣病が排尿障害や蓄尿障害などの下部尿路機能にどのように影響を与えるのか、これまでに十分な解明はされていない。2型糖尿病モデルラットを用いた今回の研究では糖尿病が炎症性サイトカインを介して前立腺血流の低下や前立腺の腫大、膀胱血流の低下を引き起こし、蓄尿障害をもたらした。タダラフィルを投与すると炎症性サイトカインを介したこの変化が抑制された。糖尿病により前立腺や膀胱の局所の炎症が蓄尿障害の原因の一つであり、タダラフィルがこれを改善する可能性が示唆され、糖尿病に伴う下部尿路障害の改善にタダラフィルが有用であることが示唆された。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Role of corticotropin-releasing factor on bladder function in rats with psychological stress.2019

    • Author(s)
      Seki M, Zha XM, Inamura S, Taga M, Matsuta Y, Aoki Y, Ito H, Yokoyama O.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 9828-9828

    • DOI

      10.1038/s41598-019-46267-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS): first analysis on survival2018

    • Author(s)
      Ito H, Wang D, Zha X, Inamura S, Seki M, Taga M, Yokoyama O.
    • Journal Title

      Life Sci.

      Volume: 23 Issue: 6 Pages: 1148

    • DOI

      10.1007/s10147-018-1309-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ラット糖尿病モデルの膀胱機能に対するphosphodiesterase 5 inhibitorの影響について2020

    • Author(s)
      小林久人、査 新民、稲村 聡、関 雅也、多賀峰克、土山克樹、福島正人、青木芳隆、伊藤秀明、横山 修
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Role of corticotropin-releasing factor on bladder function in rats with psychological stress2019

    • Author(s)
      Seki M. Zha X-M. , Ito H. , Aoki Y. , Matsuta Y. , Taga M. , Inamura S. , Yokoyama O.
    • Organizer
      EAU 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心理ストレスは膀胱CRF-muscarinic pathwayを介して蓄尿障害をもたらす2019

    • Author(s)
      関 雅也、査 新民、稲村 聡、多賀峰克、松田陽介、青木芳隆、伊藤秀明、横山 修
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Role of corticotropin-releasing factor on bladder function in rats with psychological stress2019

    • Author(s)
      Seki M, Zha X-M, Ito H, Aoki Y, Matsuta Y, Taga M, Inamura S, Yokoyama O
    • Organizer
      EAU2019
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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