Establishment of a new preventive method for recurrent urinary tract infections focusing on gut microbiota
Project/Area Number |
18K16750
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56030:Urology-related
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Research Institution | Kansai Medical University |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 尿路感染症 / 膀胱尿管逆流 / 腸内細菌叢 / プロバイオティクス / プレバイオティクス / シンバイオティクス / 逆流性腎症 / ST合剤 / 予防的抗菌薬持続投与 / 乳幼児 |
Outline of Final Research Achievements |
Approximately 30-50% of children with febrile urinary tract infections (fUTI) that develop in infancy have vesicoureteral reflux (VUR). Especially with severe VUR, fUTI may recur and lead to renal dysfunction in the future. Therefore, a small amount of antibacterial drug is taken prophylactically to prevent fUTI. However, there are cases in which fUTI recurs even after prophylactic administration of antibacterial drug. It has been reported that an increase in the proportion of Escherichia coli, which is the causative agent of fUTI, in the gut microbiota poses a risk of developing fUTI. In this study, it was clarified that the ratio of Escherichia coli in the gut microbiota was reduced by taking probiotics in addition to the preventive oral administration of antibacterial drug, and it was shown that it could be a new preventive method.
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Academic Significance and Societal Importance of the Research Achievements |
小児の尿路感染症の予防として、尿中に侵入した細菌の増殖を抑制する目的で抗菌薬の予防内服が行われてきた。しかし、抗菌薬の長期使用は耐性菌を増加させるため、長期間抗菌薬で尿路感染症を予防投与することは困難であった。今回の研究で、整腸剤を内服することで、腸内細菌叢における、尿路感染症の原因となる菌の比率を抑制する事で尿路感染症を予防する治療法は、副作用もなく安全かつ効率的な方法となる可能性が示唆された。
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Report
(4 results)
Research Products
(7 results)