| Project/Area Number |
18K16752
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Hyogo Medical University (2020-2023)
Hirosaki University (2018-2019) |
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Principal Investigator |
Yamaya Ayano 兵庫医科大学, 医学部, 講師 (50623766)
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 子宮内膜症 / NK細胞 / 不妊症 / 深部子宮内膜症 / 体外受精 / NCR / サイトカイン |
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate the relationship between NK cell function (such as activating receptors NCR and cytokine production) and infertility caused by endometriosis, and to clarify the pathophysiology of endometriosis complicated by infertility. In the peritoneal fluid of endometriosis patients, particularly those with deep infiltrating endometriosis, the number of highly cytotoxic NK cells decreased, while NK cells producing inflammatory cytokines such as TNF-α and IFN-γ increased. Additionally, NK cells in the endometrium differed between infertile patients and endometriosis patients, and the good embryo rate in endometriosis was reduced. This suggests that embryo factors contribute more to the cause of infertility in endometriosis than the immune environment of the endometrium.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、体外受精-胚移植を行った患者を対象として子宮内膜のNK細胞を解析し、子宮内膜症患者と子宮内膜症のない不妊症患者との比較を行った。その結果、子宮内膜症患者の子宮内膜では細胞傷害性の強いNK細胞の増加はなかった。良好胚を移植した場合は子宮内膜症患者の妊娠率の方が有意に良好であったものの、良好胚発生率が低く、子宮内膜症患者の不妊原因は胚因子が強く関与していると考えられた。これは、子宮内膜症患者に対して子宮内膜環境の治療よりも良好胚を得ることが先決であることが示唆され、子宮内膜症合併不妊症患者の治療方針の一案を示すことができると考える。
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