Applying Wnt/beta-catenin pathway inhibitors for the treatment of endometriosis
| Project/Area Number |
18K16774
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 子宮内膜症 / β-catenin / 線維化 / β-カテニン / Wnt/β-catenin |
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| Outline of Final Research Achievements |
We investigated whether ICG-001 and C-82, which are inhibitors of CREB-binding protein (CBP) / β-catenin, could be therapeutic agents for endometriosis. For endometriotic stromal cells, the binding of β-catenin to CBP / P300 was confirmed by immunoprecipitation. Administration of ICG-001 and C-82 significantly suppressed collagen gel contraction and suppressed cicatrization. ICG-001 and C-82 suppressed cell proliferation, induced apoptosis, and suppressed cell migration. The expression of α-SMA involved in fibrosis was suppressed by administration of ICG-001 and C-82. ICG-001 reduced endometriotic lesions in model mice.
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| Academic Significance and Societal Importance of the Research Achievements |
子宮内膜症は生殖可能年齢女性において罹患頻度が高く、月経困難症や不妊の原因となる。また日本人に多いとされる卵巣明細胞癌の発生母地となることも知られている。本研究成果はCREB-binding protein (CBP) / β-catenin阻害剤であるICG-001とC-82が子宮内膜症治療の有望な選択肢であることを示した。女性のヘルスケアの観点からも、婦人科腫瘍の観点からも臨床的に応用可能な治療選択肢を示すことができた。
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Report
(5 results)
Research Products
(5 results)
