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The mechanism of chemokine system in preterm labor

Research Project

Project/Area Number 18K16777
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionWakayama Medical University

Principal Investigator

MIKA MIZOGUCHI  和歌山県立医科大学, 医学部, 助教 (80647561)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords早産 / ケモカイン / 産科学 / サイトカイン / 切迫早産 / 前期破水 / 羊水 / プロゲステロン
Outline of Final Research Achievements

This study focuses on the chemokine network and aims to elucidate the relationship of the chemokine system in preterm labor(PTL). First, we established LPS-induced PTL mice model. Using this model, we found that the PTL rate was significantly lower in CX3CR1-deficient mice than in wild-type(WT) mice. We detected that migration of macrophages to the uterus was suppressed in CX3CR1-deficient mice, which led to the suppression of inflammatory cytokine production. CX3CL1 was significantly elevated in the serum of PTL. The administration of anti-CX3CL1 antibodies to WT-mice suppressed PTL.

Academic Significance and Societal Importance of the Research Achievements

日本の周産期死亡率は世界一低く、早産率は約5%である。しかし、早産児・特に早期早産児の死亡率はいまだに高く、先天奇形を除く周産期死亡の最大の原因を早産児が占めている。早産児の長期予後には、脳質周囲白質軟化症、未熟児網膜症、壊死性腸炎等の問題が指摘される。児の予後を改善するためには、早産そのものを減少させることが重要である。現在は安静・子宮収縮抑制剤など対症療法が治療の中心で、それだけでは分娩に至ってしまう症例も多い。早産の詳細なメカニズムを解明することが病態解明・治療に繋がると考え、早産の新たな治療戦略の基盤を構築することが、この研究成果の意義である。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 症例 夫婦ともにEhlers-Danlos症候群を有し常位胎盤早期剝離に至った1例2022

    • Author(s)
      溝口 美佳、平山 純也、中田 久実子、南條 佐輝子、小林 彩、太田 菜美、八木 重孝、南 佐和子、井箟 一彦
    • Journal Title

      産婦人科の実際

      Volume: 71 Issue: 6 Pages: 673-677

    • DOI

      10.18888/sp.0000002185

    • ISSN
      0558-4728
    • Year and Date
      2022-06-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice2018

    • Author(s)
      Mizoguchi M, Ishida Y, Nosaka M, Kimura A, Kuninaka Y, Yahata T, Nanjo S, Toujima S, Minami S, Ino K, Mukaida N, Kondo T
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0207085-e0207085

    • DOI

      10.1371/journal.pone.0207085

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 夫婦ともにEhlers-Danlos症候群を有し常位胎盤早期剥離に至った1例2021

    • Author(s)
      溝口美佳
    • Organizer
      日本周産期・新生児学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 夫婦ともにEhlers-Danlos症候群を有し妊娠・出産に至った1例2021

    • Author(s)
      溝口美佳
    • Organizer
      日本遺伝カウンセリング学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Advanced hepatoid carcinoma of the ovary with lung and liver metastases2019

    • Author(s)
      Mika Mizoguchi, Kumiko Nakata, Yoshihiro Takiguchi, Tamaki Yahata, Sakiko Nanjo, Noriyuki Sasaki, Nami Ota, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino
    • Organizer
      第71回 日本産婦人科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Prevention of LPS-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice2018

    • Author(s)
      Mika Mizoguchi, Tamaki Yahata, Sakiko Nanjo, Madoka Yamamoto, Sawako Minami, Kazuhiko Ino
    • Organizer
      第70回 日本産婦人科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 過去10年間当院で管理した18トリソミー症例の検討2018

    • Author(s)
      溝口美佳、八幡環、太田菜美、八木重孝、熊谷健、南佐和子、井箟一彦
    • Organizer
      第54回 日本周産期・新生児学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] A case report of advanced hepatoid carcinoma of the ovary with lung and liver metastases2018

    • Author(s)
      Mika Mizoguchi, Kumiko Nakata, Naoyuki Iwahashi, Yoshihiro Takiguchi, Tamaki Yahata, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino
    • Organizer
      The 17th BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIRTY
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2025-01-30  

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