| Project/Area Number |
18K16799
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HHV-6 / 不育症 / 反復着床不全 / 子宮内膜フローラ / human herpesvirus 6 / HHV6 / 習慣流産 / 不妊症 / human herpesvirus 7 / 生殖不全 |
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| Outline of Final Research Achievements |
Using endometrial specimens collected from patients with recurrent pregnancy loss attending our clinic, we performed real time PCR to investigate the presence or absence of HHV-6 and its association with recurrent pregnancy loss. However, HHV-6 DNA was not detected. The association between HHV-6 and recurrent pregnancy loss was considered to be low. Next, patients with recurrent implantation failure at a specialized infertility treatment hospital were examined. DNA collected from the endometrium and examined for the presence of HHV-6 DNA. But the detection rate was very low (2.3%), and even in HHV-6 DNA-positive cases, pregnancy and delivery were observed. In conclusion, HHV-6 is unlikely to be associated with recurrent pregnancy loss and infertility in Japan.
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| Academic Significance and Societal Importance of the Research Achievements |
海外のデータでは、子宮内膜HHV6と不妊症（反復着床不全）との関連性が指摘されていたが、本邦においてのデータはこれまで無かった。また不育症患者とHHV6との関連性については、これまで海外においても報告がなかった。反復着床不全および不育症の原因は不明なことも多く、挙児を希望する女性において重要な課題であった。そこで本邦における不育症患者や着床不全患者の子宮内膜等からDNAを抽出し、HHV-6 DNAの有無を検討を行った。しかしHHV-6DNAの検出率は非常に低く、またHHV-6陽性例からも妊娠出産が確認されており、不育症や不妊症との関連性は低いと考えられた。
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