| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Although no prevention or treatments have been established for Age-related hearing loss (AHL), recent studies have suggested that suppression of oxidative stress leads to inhibition of AHL progression. NRF2 is a master transcription factor that regulates various antioxidant proteins and cytoprotection factors. We used one transgenic mice, in which NRF2 is activated. We compared 12-month-old mice. Histological analysis showed that cochlear degeneration was ameliorated in the transgenic mice. Auditory brainstem response thresholds in the transgenic mice were significantly lower than those in the wild type mice. Immunohistochemical analysis suggested that oxidative stress accumulation was attenuated in the cochlea of the transgenic mice. Thus, we concluded that NRF2 pathway activation protects the cochlea from oxidative damage during aging. Nrf2 activation drugs are expected to be effective in the prevention of AHL.
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