• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analyzing lipid-metabolizing enzymes under endoplasmic reticulum stress in inner ear cells and elucidating the cause of sensorineural hearing loss

Research Project

Project/Area Number 18K16829
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionYamagata University

Principal Investigator

Matsui Hirooki  山形大学, 医学部, 助教 (60594322)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords内耳障害 / 感音難聴 / コルチ器 / 脂質代謝酵素 / ジアシルグリセロールキナーゼ / 有毛細胞 / らせん神経節 / 難聴 / 小胞体 / リン脂質代謝酵素 / DGK / 外有毛細胞 / 内耳 / リン脂質代謝異常 / 小胞体ストレス
Outline of Final Research Achievements

Acoustic exposure in guinea pigs showed that DGKζ translocated from the nuclei into the cytoplasm in outer hair cells. DGKζ was present in the nuclei in the spiral ganglion cells, but acoustic exposure did not change its intracellular localization. In addition, we reported that the hearing threshold of Alport syndrome was increased for long-term observation, which is a sensorineural hearing loss disease. We also reported that a government program in the purchase of hearing aids for children with mild or moderate hearing loss is useful.

Academic Significance and Societal Importance of the Research Achievements

リン脂質代謝酵素に内耳における音響暴露における細胞内局在について解析し論文として報告した。感音難聴疾患について臨床研究を行い論文で報告した。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2021 2020 2019 2018

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 軽度・中等度難聴児補聴器購入支援事業の検2020

    • Author(s)
      松井 祐興, 伊藤 吏, 窪田 俊憲, 新川 智佳子, 千葉 寛之, 米澤 裕美, 欠畑 誠治
    • Journal Title

      Audiology Japan

      Volume: 63 Pages: 242-249

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of diacylglycerol kinaseζin guinea pig cochlea and its functional implication under noise exposure stress conditions2019

    • Author(s)
      Shinkawa C, Ito T, Hozumi Y, Chiba M, Matsui H, Goto K, Kakehata S
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 151 Pages: 461-474

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 長期経過観察を行ったAlport症候群例2019

    • Author(s)
      松井祐興, 伊藤吏, 窪田俊憲, 新川智佳子, 千葉寛之, 米澤裕美, 欠畑誠治
    • Journal Title

      Audiology Japan

      Volume: 62 Pages: 299-306

    • NAID

      130007706269

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mid-Frequency Hearing Loss Is Characteristic Clinical Feature of OTOA-Associated Hearing Loss2019

    • Author(s)
      Sugiyama、Moteki、Kitajiri、Kitano、Nishio、Yamaguchi、Wakui、Abe、Ozaki、Motegi、Matsui、Teraoka、Kobayashi、Kosho、Usami
    • Journal Title

      Genes

      Volume: 10 Issue: 9 Pages: 715-732

    • DOI

      10.3390/genes10090715

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 10年間の口腔・咽頭・頸部食道異物の検討2018

    • Author(s)
      松井祐興, 鈴木 豊, 岡崎 雅, 新川 智佳子, 荒木 直人
    • Journal Title

      耳鼻咽喉科臨床111(10) 701-706, 2018

      Volume: 111 Pages: 701-706

    • NAID

      130007493391

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 縦隔気管孔造設を行った頸部気管腺様嚢胞癌症例2018

    • Author(s)
      松井祐興, 鈴木豊, 岡崎雅, 新川智佳子, 荒木直人
    • Journal Title

      頭頸部外科

      Volume: 28 Pages: 361-368

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【耳の検査のコツとピットフォール】 耳鏡検査と内視鏡検査(解説/特集)2018

    • Author(s)
      松井祐興,欠畑誠治
    • Journal Title

      JOHNS

      Volume: 34 Pages: 815-818

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] COVID-19感染予防対策における音の遮蔽と語音聴取に対する影響についての検討2021

    • Author(s)
      松井祐興、伊藤吏、窪田俊憲、新川智佳子、天野彰子、千葉寛之、石山弘将、綿貫敬介、不破大介、欠畑誠治
    • Organizer
      第66回 日本聴覚医学会総会・学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 耳硬化症における聴覚検査の検討2020

    • Author(s)
      松井祐興, 伊藤吏, 窪田俊憲, 新川智佳子, 千葉寛之, 欠畑誠治
    • Organizer
      第65回日本聴覚医学会総会・学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 耳硬化症に対するTEESアブミ骨手術における術後36か月の聴力成績の検討2020

    • Author(s)
      松井祐興, 伊藤吏, 窪田俊憲, 新川智佳子, 欠畑誠治
    • Organizer
      第30回日本耳科学会総会・学術講演会,
    • Related Report
      2020 Research-status Report
  • [Presentation] Surgical evaluation of cholesteatoma secondary to tympanic perforation2019

    • Author(s)
      Hirooki Matsui, Tsukasa Ito, Toshinori Kubota, Takatoshi Furukawa, Takanari Goto, Kazunori Futai, Chihiro Watanabe, Seiji Kakehata
    • Organizer
      World Congress on Endoscopic Surgery 3.0, Boston, USA
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 当院におけるAlport症候群に関する聴覚管理の問題点2019

    • Author(s)
      松井祐興, 伊藤吏, 窪田俊憲, 新川智佳子, 千葉寛之, 米澤裕美, 欠畑誠治
    • Organizer
      第63回聴覚医学会, 神戸
    • Related Report
      2019 Research-status Report
  • [Presentation] 経外耳道的内視鏡下耳科手術を行った中耳腺腫症例.2019

    • Author(s)
      松井祐興, 伊藤 吏, 窪田 俊憲, 古川孝俊, 後藤崇成, 欠畑誠治
    • Organizer
      第29回日本頭頸部外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Congenital Cholesteatoma Removal Using Transcanal Endoscopic Ear Surgery (TEES)2018

    • Author(s)
      Hirooki Matsui, Tsukasa Ito, Toshinori Kubota, Takatoshi Furukawa, Seiji Kakehata
    • Organizer
      VII international workshop on endoscopic ear surgery
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 癒着性中耳炎に対する内視鏡下耳科手術の治療成績2018

    • Author(s)
      松井祐興, 伊藤吏, 窪田俊憲, 古川孝俊, 阿部靖弘, 鈴木祐輔, 後藤崇成, 欠畑誠治
    • Organizer
      第28回耳科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 当院におけるAlport症候群に関する聴覚管理の問題点2018

    • Author(s)
      松井祐興, 伊藤吏, 窪田俊憲, 新川智佳子, 千葉寛之, 米澤裕美, 欠畑誠治
    • Organizer
      第63回聴覚医学会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi