| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Sudden hearing loss is cryptogenic acute sensorineural deafness. Due to the significant increase in the number of patient and low treatment efficiency, it is urgent to elucidate the pathogenic mechanism. Although it is essential to establish a model animal for hearing loss, models such as mainstream drug administration and noise exposure cannot completely explain the mechanism of the disease. We focused on “mental stress” as a cause of hearing loss and clarified the possibility that repetitive cold-treated mice could be stress-induced deafness model animals. Our findings suggested that activation of the auditory pathway in the central nervous system rather than the cochlear defect may be one cause of stress-induced hearing loss. We believe that our deafness model mice will be a useful tool for elucidating the mechanism of sudden hearing loss.
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