Studies on the causative fungi of fungal sinusitis and disease control by analysis of microbiota

• Project/Area Number: 18K16853
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Tohoku University
• Principal Investigator: Risako Kakuta 東北大学, 大学病院, 助教 (40596095)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 副鼻腔真菌症

Outline of Final Research Achievements

This study was conducted with the aim of controlling the disease by identifying the causative fungi of fungal sinusitis and clarifying its microbiological characteristics. In this study, both invasive and non-invasive fungal sinusitis were included. The causative fungis were identified by genetic analysis. Microbiota analysis revealed that the microbiota is composed of various bacterial species.

Academic Significance and Societal Importance of the Research Achievements

これまで、副鼻腔真菌症の原因真菌を菌種レベルで明らかにした報告はほとんど見られなかったが、本検討において副鼻腔真菌症の主な原因真菌が菌種レベルで明らかとなった。さらに副鼻腔真菌症の微生物叢についても明らかになった。近年高齢化や疾患および治療が多様化しており、副鼻腔真菌症は今後も増加することが考えられる。本検討結果は、今後の副鼻腔真菌症の治療のさらなる発展に貢献できることが期待される。

Research Products

• [Journal Article] Genomic characteristics of listeria monocytogenes causing invasive listeriosis in Japan. (2021)
  • Author(s): Baba H, Kanamori H, Kakuta R, Sakurai H, Oshima K, Aoyagi T, Kaku M.
  • Journal Title: Diagn Microbiol Infect Dis. Volume: 99 Issue: 3 Pages: 115223-115223
  • DOI: 10.1016/j.diagmicrobio.2020.115233
  • Peer Reviewed
• [Journal Article] Molecular characteristics of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in Japan: Predominance of CTX-M-15 and emergence of hypervirulent clones. (2020)
  • Author(s): Kakuta N, Nakano R, Nakano A, Suzuki Y, Masui T, Horiuchi S, Kakuta R, Tsubaki K, Ogawa M, Yano H.
  • Journal Title: Int J Infect Dis. Volume: 98 Pages: 281-2886
  • DOI: 10.1016/j.ijid.2020.06.083
  • Peer Reviewed / Open Access
• [Journal Article] First Two Cases of Infected Aortic Aneurysm Caused by Non-Vaccine Streptococcus pneumoniae Serotype 23A. (2020)
  • Author(s): Kakuta R, Nakano R, Yano H, Ozawa D, Ohta N, Matsuoka T, Motoyoshi N, Kawamoto S, Saiki Y, Katori Y, Kaku M.
  • Journal Title: Ann Lab Med. Volume: 40 Issue: 3 Pages: 270-273
  • DOI: 10.3343/alm.2020.40.3.270
  • Peer Reviewed / Open Access
• [Presentation] 宮城県における侵襲性リステリア症の分子疫学的検討 (2020)
  • Author(s): 馬場 啓聡, 金森 肇, 角田 梨紗子, 桜井 博毅, 大島 謙吾, 青柳 哲史, 賀来 満夫
  • Organizer: 日本臨床腸内微生物学会総会・学術集会
• [Presentation] 環境中に分布するPseudomonas属が保有するカルバペネマーゼ遺伝子とその伝達性について (2020)
  • Author(s): 鈴木 由希 中野 竜一, 中野 章代, 角田 梨紗子, 堀内 沙央里, 矢野 寿一, 角田 尚紀, 中島 一敏
  • Organizer: 日本化学療法学会
• [Presentation] スエヒロタケが原因と考えられた眼窩骨膜下膿瘍の一例 (2018)
  • Author(s): 角田梨紗子
  • Organizer: 第6回日本耳鼻咽喉科感染症・エアロゾル学会総会・学術講演会