A route of reproduction of the olfactory field by brain transparence
| Project/Area Number |
18K16863
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 脳透明化 / 嗅覚中枢再生 / 嗅神経芽細胞 / Rostral migratory stream / 認知症 / 神経芽細胞 / IGF-1 / 透明化 / 嗅神経 |
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| Outline of Final Research Achievements |
In the brain, neurogenesis is seen only hippocampus and olfactory bulb. Neuroblasts occur lateral ventricle, and carry from there to olfactory bulb. We can know the clear neuropoietic mechanism more by catching the change three-dimensionally. During this study period, we transparentized 500μm thickness in the brain of mouse and depicted only a neuroblast seen in that by immunostaining. We confirmed the figure that a neuroblast shifted from lateral ventricle to olfactory bulb in a spiral three-dimensionally.
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| Academic Significance and Societal Importance of the Research Achievements |
今後の研究目標として、嗅神経芽細胞の神経新生を促進する事で、嗅覚の再生につながる可能性について検討を予定しているため、促進因子の投与と非投与との変化を明らかにすることが必要となる。
今回の研究成果は、神経新生の動態を立体的に行う事により、その投与、非投与での差を一目瞭然とできる可能性があると考えられる。
この研究により、認知症の前駆症状とも言われる嗅覚障害の改善から、認知症予防につながる可能性を考えている。
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Report
(3 results)
Research Products
(8 results)
