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A route of reproduction of the olfactory field by brain transparence

Research Project

Project/Area Number 18K16863
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionKanazawa Medical University

Principal Investigator

NAKAMURA Yukari  金沢医科大学, 医学部, 助教 (80769117)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords脳透明化 / 嗅覚中枢再生 / 嗅神経芽細胞 / Rostral migratory stream / 認知症 / 神経芽細胞 / IGF-1 / 透明化 / 嗅神経
Outline of Final Research Achievements

In the brain, neurogenesis is seen only hippocampus and olfactory bulb. Neuroblasts occur lateral ventricle, and carry from there to olfactory bulb. We can know the clear neuropoietic mechanism more by catching the change three-dimensionally. During this study period, we transparentized 500μm thickness in the brain of mouse and depicted only a neuroblast seen in that by immunostaining. We confirmed the figure that a neuroblast shifted from lateral ventricle to olfactory bulb in a spiral three-dimensionally.

Academic Significance and Societal Importance of the Research Achievements

今後の研究目標として、嗅神経芽細胞の神経新生を促進する事で、嗅覚の再生につながる可能性について検討を予定しているため、促進因子の投与と非投与との変化を明らかにすることが必要となる。
今回の研究成果は、神経新生の動態を立体的に行う事により、その投与、非投与での差を一目瞭然とできる可能性があると考えられる。
この研究により、認知症の前駆症状とも言われる嗅覚障害の改善から、認知症予防につながる可能性を考えている。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2019 2018

All Journal Article (1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] ー2019

    • Author(s)
      ー
    • Journal Title

      ー

      Volume: ー

    • Related Report
      2018 Research-status Report
  • [Presentation] The effect of the neuroblast in the brain with intranasal administration of IGF-12019

    • Author(s)
      中村 有加里
    • Organizer
      Rhinoworld 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 経鼻的投与したIGF-1の脳内神経芽細胞遊走へ及ぼす影響2019

    • Author(s)
      中村 有加里
    • Organizer
      第120回日本耳鼻咽喉科学会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Presentation] 脳透明化による嗅覚中枢描出の検討2019

    • Author(s)
      中村 有加里
    • Organizer
      第58回日本鼻科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] IGF-1の経鼻投与による脳内新生ニューロン移動に対する促進効果の検討2019

    • Author(s)
      中村 有加里
    • Organizer
      第37回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Promoting the neuron neogenesis in the brain by nasal administration of IGF-12018

    • Author(s)
      Yukari Nakamura
    • Organizer
      Rhinoworld
    • Related Report
      2018 Research-status Report
  • [Presentation] IGF-1の経鼻投与による脳内新生ニューロン移動促進効果の検討2018

    • Author(s)
      中村 有加里
    • Organizer
      第52回日本味と匂い学会
    • Related Report
      2018 Research-status Report
  • [Book] ー2019

    • Author(s)
      ー
    • Publisher
      ー
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

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