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Relationship between metabolic heterogeneity and immune marker expressions in head and neck cancers

Research Project

Project/Area Number 18K16870
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionKyoto University

Principal Investigator

Kikuchi Masahiro  京都大学, 医学研究科, 助教 (90443564)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords頭頸部癌 / FDG PET / 糖代謝 / 不均一 / PD-L1 / 免疫細胞 / バイオマーカー / 口腔癌 / 末梢血可溶性PD-L1 / FDG PET/CT / texture analysis / CD8+細胞 / テキスチャ解析 / MTV / correlation / 腫瘍内免疫マーカーの発現予測 / 腫瘍微小環境 / 免疫マーカー
Outline of Final Research Achievements

The aim of this study was to evaluate pre-operative FDG PET/CT texture features and soluble PD-L1 (sPD-L1) expression in circulation as a factor predicting PD-L1 expression in tumor-microenvironments in patients with head and neck squamous cell carcinoma who underwent definitive surgery. PD-L1 expression in surgically resected specimens were evaluated using immunohistochemistry and compared with PET texture features (SUV and textural indices) and sPD-L1 concentration in preoperative serum using enzyme-linked immunosorbent assay. Patients with high SUVmax, patients with high metabolic heterogeneity, and patients with high serum level of sPD-L1 showed high PD-L1 expression in immune cells.
Preoperative FDG PET/CT texture features and serum level of sPD-L1 were predictive markers for PD-L1 expressions of immune cells.

Academic Significance and Societal Importance of the Research Achievements

腫瘍微小環境における免疫細胞のPD-L1発現の役割は不明であるが、腫瘍細胞のPD-L1発現と同様、腫瘍浸潤リンパ球の活性を抑制する役割があると考えられている。FDG PET検査ならびに末梢血可溶性PD-L1測定は非侵襲的な検査であり、手術前に腫瘍内の免疫細胞のPD-L1発現を評価することが可能である。これらは頭頸部癌患者の生命予後予測ならびに抗PD-1薬・抗PD-L1薬といった免疫チェックポイント阻害剤の効果予測の新たなバイオマーカーになることが期待される。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Successful Treatment of a Mixed Neuroendocrine-Nonneuroendocrine Neoplasm of the Colon with Metastases to the Thyroid Gland and Liver.2020

    • Author(s)
      Kanazawa Y, Kikuchi M, Imai Y, Katakami N, Kaihara S, Shinohara S.
    • Journal Title

      Case Rep Otolaryngol

      Volume: eCollection 2020. Pages: 1-5

    • DOI

      10.1155/2020/5927610

    • NAID

      120006956722

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-time imaging of head and neck squamous cell carcinomas using confocal micro-endoscopy and applicable dye: A preliminary study.2020

    • Author(s)
      Shinohara S, Funabiki K, Kikuchi M, Takebayashi S, Hamaguchi K, Hara S, Yamashita D, Imai Y, Mizoguchi A.
    • Journal Title

      Auris Nasus Larynx.

      Volume: Epub ahead of print Issue: 4 Pages: 668-675

    • DOI

      10.1016/j.anl.2020.02.001

    • NAID

      130008150686

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term olfactory function outcomes after pituitary surgery by endoscopic endonasal transsphenoidal approach2020

    • Author(s)
      Kuwata Fumihiko、Kikuchi Masahiro、Ishikawa Masaaki、Tanji Masahiro、Sakamoto Tatsunori、Yamashita Masaru、Matsunaga Mami、Omori Koichi、Nakagawa Takayuki
    • Journal Title

      Auris Nasus Larynx

      Volume: 47 Issue: 2 Pages: 227-232

    • DOI

      10.1016/j.anl.2019.07.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Value of Fused PET/MRI for Surgical Planning in Patients With Oral/Oropharyngeal Carcinoma.2019

    • Author(s)
      Hayashi K, Kikuchi M, Imai Y, Yamashita D, Hino M, Ito K, Shimizu K, Harada H, Shinohara S
    • Journal Title

      Laryngoscope

      Volume: 印刷中 Issue: 2 Pages: 367-374

    • DOI

      10.1002/lary.27911

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical Usefulness of Positron Emission Tomography for Head and Neck Cancer from Current to Near Future2018

    • Author(s)
      Kikuchi Masahiro
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 111 Issue: 12 Pages: 789-802

    • DOI

      10.5631/jibirin.111.789

    • NAID

      130007539268

    • ISSN
      0032-6313, 1884-4545
    • Related Report
      2018 Research-status Report
  • [Presentation] PD-L1 expression of immune cells, PD-1+ tumor infiltrating lymphocytes and CD68+ macrophages in surgical specimens are associated with improved survival and lower recurrence in patients with advanced oral squamous cell carcinoma2019

    • Author(s)
      Masahiro Kikuchi, Daisuke Yamashita, et al.
    • Organizer
      7th WORLD CONGRESS of the International Academy of Oral Oncology (IAOO)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Endoscopic Endonasal Surgery for Sinonasal Carcinoma2019

    • Author(s)
      Masahiro Kikuchi, Takayuki Nakagawa, et al.
    • Organizer
      第15回日本台湾耳鼻咽喉科・頭頸部外科会議
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 口腔癌微小環境における糖代謝と免疫マーカー発現の関連性の検討2019

    • Author(s)
      菊地正弘、山下大祐、篠原尚吾、原重雄、大森孝一
    • Organizer
      第29回日本頭頸部外科学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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