Analysis of the IL-22 regulation in Eosinophilic Rhinosinusitis with aspirin intolerance

• Project/Area Number: 18K16891
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Okayama University
• Principal Investigator: Higaki Takaya 岡山大学, 大学病院, 助教 (30587407)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 好酸球性副鼻腔炎 / IL-22 / 好酸球 / 慢性副鼻腔炎 / IL-22受容体 / アスピリン不耐症 / アスピリン喘息

Outline of Final Research Achievements

Eosinophilic rhinosinusitis is refractory. Many cytokines form complicated networks and associated with clinical condition.IL -22 is cytokine which came to attract attention relatively recently, but the details are still unknown about what kind of role IL -22 has in the pathogenesis of eosinophilic rhinosinusitis.
We focused on the role of IL-22 in eosinophilic rhinosinusitis. We examined in particular how IL -22 act in patients with sinusitis with aspirin intolerance.
As a result, IL -22 inhibited eosinophilic inflammation, but it was found that IL-22 receptor expression decreased in the patients of the aspirin intolerance. Our result indicate that the decrease of IL-22　receptor attenuates anti-inflammatory effect of IL -22.

Academic Significance and Societal Importance of the Research Achievements

好酸球性副鼻腔炎は、難治性の副鼻腔炎であり手術やステロイド薬の投与を中心とした治療法では十分な制御が出来ない場合もあり、病態の解明と治療法の開発が求められている。今回の研究成果は、IL-22が好酸球性副鼻腔炎において制御的な役割を持つ一方で、その受容体の発現が低下することでIL-22の制御作用が低下し、好酸球性副鼻腔炎の増悪へとつながる可能性を示唆している。
この研究結果は、IL-22をターゲットとした好酸球性副鼻腔炎の治療の可能性について示唆するものとなる。今後、IL-22の受容体発現のメカニズムの解明を進めることで、新たな治療法へとつながることが期待される。

Research Products

• [Journal Article] INVOLVEMENT OF IL-22 AND IL-22 RECEPTOR SIGNALING TO THE EOSINOPHILIC INFLAMMATION OF CHRONIC RHINOSINUSITIS (2020)
  • Author(s): 檜垣貴哉
  • Journal Title: Japanese Journal of Allergology Volume: 69 Issue: 9 Pages: 897-899
  • DOI: 10.15036/arerugi.69.897
  • NAID: 130007938961
  • ISSN: 0021-4884, 1347-7935
• [Presentation] Involvement of IL-22 and IL-22 receptor signaling to the eosinophilic inflammation of chronic rhinosinusitis (2019)
  • Author(s): Takaya Higaki, Mitsuhiro Okano, Minori Noda, Shin Kariya, Takahisa Koyama, Kazunori Nishizaki
  • Organizer: CEORL-HNS 2019
  • Int'l Joint Research
• [Presentation] 好酸球性上気道炎症におけるIL-22およびIL-22受容体発現の制御作用についての解析 (2019)
  • Author(s): 檜垣貴哉、岡野光博、野田実里、春名威範、假谷伸、西﨑和則
  • Organizer: 第37回 日本耳鼻咽喉科免疫アレルギー学会
• [Presentation] IL-22、IL-22受容体の好酸球性副鼻腔炎病態への関与について (2018)
  • Author(s): 檜垣貴哉
  • Organizer: 第57回 日本鼻科学会