| Project/Area Number |
18K16897
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Matayoshi Sen 琉球大学, 医学部, 委託非常勤講師 (60448587)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | リゾフォスファチジン酸 / LPA / 頭頸部癌 / 上咽頭癌 / LPA5 |
|---|
| Outline of Final Research Achievements |
Lysophosphatidic acid (LPA) is a bioactive lipid having various functions in the human body, and it is known that LPA stimulation to cancer cells acts to enhance cell proliferation ability and migration ability. LPA receptors are known to have six subtypes of LPA1-6. There are many unclear points about the difference in distribution and expression level in head and neck cancer. In addition, compared to the classically known LPA1-3, the genetic genealogy of LPA4-6 newly discovered after 2000 is said to be different, and there are many unclear points about its action. We investigated the mRNA expression levels of LPA receptors(LPA1-6) in patients with nasopharyngeal carcinoma. It was suggested that the LPA1 / LPA5 ratio may be high in radiation-resistant cases.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで頭頸部癌におけるLPAに関する研究は少なく、上咽頭癌についての報告はほとんどない。各種頭頸部癌に対してLPA受容体の発現分布や発現様式について調べることは予後予測因子の発見や創薬のターゲットとなり得る。
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