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Relationship between genetic analysis and language development in children with congenital hearing loss

Research Project

Project/Area Number 18K16899
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionNippon Medical School (2020-2022)
Yokohama City University (2018-2019)

Principal Investigator

Sakuma Naoko  日本医科大学, 医学部, 講師 (40567541)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords遺伝性難聴 / 先天性難聴 / 言語発達 / 遺伝学的検査 / 難聴 / 遺伝子解析
Outline of Final Research Achievements

In this study, we identified the causative mutations and evaluated language development in children with congenital sensorineural hearing loss. In most cases, as they moved up through the grades, the scores on the language development tests were increased. Some cases in the third grade and above showed the result above the average for the children with normal hearing. It was thought that the language development in children with congenital hearing loss was affected not only by the difference of causative genes, but also by the deafness period and social background.
The importance of early diagnosis of hearing loss and appropriate hearing aid was recognized for language development in children with hearing loss. The genetic test is need for early diagnosis of hearing loss and selection of appropriate treatment.

Academic Significance and Societal Importance of the Research Achievements

感覚器障害戦略研究で提唱された ALADJINによる言語発達検査を行うことにより、遺伝性難聴症例の言語発達の結果が導きだされたことにより、難聴に対する遺伝学的検査およびALADJINの有用性が検討でき、さらには新生児聴覚スクリーニング後の早期からの補聴器装用やリハビリの介入などを進める基準作成へつながることが期待できる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results)

  • [Presentation] 遺伝性難聴症例における人工内耳術後成績の検討2019

    • Author(s)
      佐久間 直子
    • Organizer
      第64回日本聴覚医学会総会・学術講演会
    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

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