| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We firstly, analyzed mircroarray data of corneal epithelial cells and epidermal keratinocyte, which is a model showing the pathological condition on the severe ocular surface disorders, such as Stevens-Johnson syndrome, ocular cicatricial pemphigoid, and severe thermal/chemical injury, and 8877 of small molecular compounds, which enhanced the corneal related genes, were selected. Using CMap data base, candidate compounds were narrowed down. Among them, 13 candidate were found with more than 90 of score, and 48 candidates were observed with less than 90 of score, indicating the possible induction of corneal-related gene expression profile. However, no small molecule compounds were capable of reprogramming into corneal epithelial cells was found, although the treatment period and the combination of compounds were tested by various conditions,
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