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Investigating a neural network and establishing methods of objective evaluation for photophobia

Research Project

Project/Area Number 18K16939
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionJikei University School of Medicine

Principal Investigator

Horiguchi Hiroshi  東京慈恵会医科大学, 医学部, 講師 (90385360)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords羞明 / 他覚的計測 / 明るさ感覚 / ダイナミックレンジ / 心理物理学 / 遮光眼鏡 / 心理物理 / 眼疾患 / 脳内メカニズム / fMRI / 心理物理的計測 / 神経画像法 / 知覚の客観的評価 / ヒト / メラノプシン / 客観的評価 / 心理物理学的手法 / 他覚的評価
Outline of Final Research Achievements

Ocular disease can cause severe photophobia even with relatively weak light sources. Photophobia, like pain, varies in threshold and intensity depending on the individual's physical and environmental conditions. In this study, we 1) presented the results of an effective psychophysical method to measure the "dynamic range of brightness perception," 2) reported on the degeneration of the visual neural basis using neuroimaging of patients with ocular diseases that can cause photophobia, and 3) reported on a low-luminance device that enabled surgery in a patient with pathological photophobia who was inoperable with normal light intensity.

Academic Significance and Societal Importance of the Research Achievements

タブレットPCを用いた明るさ感覚のダイナミックレンジの簡易計測の開発により、羞明を日常的に感じやすい眼疾患患者において、弁別可能な輝度範囲が視覚正常者より狭い傾向にあることが判明した。本研究で得られた結果と更なる研究によって、現在自覚的な感覚に基づいて処方している遮光眼鏡の処方を、客観的なデータに基づいて最適な遮光眼鏡を処方できる可能性がある。また、明るさ感覚のダイナミックレンジの順応速度に対しても知見を得たことから、今後より順応速度に焦点を当てた研究を継続する契機となった。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (23 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 8 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 8 results)

  • [Int'l Joint Research] The Hebrew University(イスラエル)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Stanford University/New York University(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Stanford University/New York University/Indiana University(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] The Hebrew University(イスラエル)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Effectiveness of the Heads-Up Surgery System for Retinal Surgery in a Patient with Severe Photophobia2021

    • Author(s)
      Saito Yuka、Horiguchi Hiroshi、Mizobuchi Kei、Katagiri Satoshi、Gunji Hisato、Nakano Tadashi
    • Journal Title

      International Medical Case Reports Journal

      Volume: Volume 14 Pages: 583-589

    • DOI

      10.2147/imcrj.s326803

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of meteorological factors with the frequency of primary rhegmatogenous retinal detachment in Japan2021

    • Author(s)
      Iida Masanobu、Horiguchi Hiroshi、Katagiri Satoshi、Shirakashi Yuka、Yamada Yuki、Gunji Hisato、Nakano Tadashi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 9559-9559

    • DOI

      10.1038/s41598-021-88979-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inspection of the lens thickness with preoperative biometric measurements prevents an erroneous interpretation of posterior capsule during FLACS2021

    • Author(s)
      Kurosawa Mei、Horiguchi Hiroshi、Shiba Takuya、Nakano Tadashi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 9702-9702

    • DOI

      10.1038/s41598-021-89209-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient measurements for the dynamic range of human lightness perception2021

    • Author(s)
      Horiguchi Hiroshi、Suzuki Eiji、Kubo Hiroyuki、Fujikado Takashi、Asonuma Sanae、Fujimoto Chihomi、Tatsumoto Muneto、Fukuchi Takeo、Sakaue Yuta、Ichimura Mika、Kurimoto Yasuo、Yamamoto Midori、Nakadomari Satoshi
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: - Issue: 3 Pages: 432-438

    • DOI

      10.1007/s10384-020-00808-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] V1 Projection Zone Signals in Human Macular Degeneration Depend on Task Despite Absence of Visual Stimulus.2021

    • Author(s)
      Masuda Y, Takemura H, Terao M, Miyazaki A, Ogawa S, Horiguchi H, Nakadomari S, Matsumoto K, Nakano T, Wandell BA, Amano K.
    • Journal Title

      Curr Biol.

      Volume: 31 Issue: 2 Pages: 406-412

    • DOI

      10.1016/j.cub.2020.10.034

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Posture-related ocular cyclotorsion during cataract surgery with an ocular registration system2020

    • Author(s)
      Terauchi Ryo、Horiguchi Hiroshi、Ogawa Tomoichiro、Shiba Takuya、Tsuneoka Hiroshi、Nakano Tadashi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 2136-2136

    • DOI

      10.1038/s41598-020-59118-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Posterior capsule rupture with FLACS due to erroneous interpretation of a high OCT intensity area in anterior vitreous2020

    • Author(s)
      Horiguchi Hiroshi、Kurosawa Mei、Shiba Takuya
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 19 Pages: 100811-100811

    • DOI

      10.1016/j.ajoc.2020.100811

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage2019

    • Author(s)
      Takemura Hiromasa、Ogawa Shumpei、Mezer Aviv A.、Horiguchi Hiroshi、Miyazaki Atsushi、Matsumoto Kenji、Shikishima Keigo、Nakano Tadashi、Masuda Yoichiro
    • Journal Title

      NeuroImage: Clinical

      Volume: 23 Pages: 101826-101826

    • DOI

      10.1016/j.nicl.2019.101826

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage2018

    • Author(s)
      Yoshimine Shoyo、Ogawa Shumpei、Horiguchi Hiroshi、Terao Masahiko、Miyazaki Atsushi、Matsumoto Kenji、Tsuneoka Hiroshi、Nakano Tadashi、Masuda Yoichiro、Pestilli Franco
    • Journal Title

      Brain Structure and Function

      Volume: 223 Issue: 8 Pages: 3889-3900

    • DOI

      10.1007/s00429-018-1702-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Pharmacological Mydriatic Pupil-to-Limbal Diameter Ratio as an Intuitive Predictor for the Risk of Intraoperative Floppy Iris Syndrome2018

    • Author(s)
      Terauchi Yurika、Horiguchi Hiroshi、Shiba Takuya
    • Journal Title

      Journal of Ophthalmology

      Volume: 2018 Pages: 1-7

    • DOI

      10.1155/2018/2837934

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 日常生活で感じる不快な「光のノイズ」と羞明. ランチョンセミナー13.2020

    • Author(s)
      堀口浩史
    • Organizer
      第124回日本眼科学会総
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 臨床研究アップデート. 羞明の理解とその克服のために.2020

    • Author(s)
      堀口浩史
    • Organizer
      第553回慈眼会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 羞明の理解とその克服のために2020

    • Author(s)
      堀口浩史
    • Organizer
      千葉県眼科医会総会学術講演
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] シンポジウム3. 羞明の理解とその克服のために2019

    • Author(s)
      堀口浩史
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] モーニングセミナー2. 羞明のメカニズムの解明のために2019

    • Author(s)
      堀口浩史
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ランチョンセミナー20. 日常生活で感じる不快な「光のノイズ」と羞明2019

    • Author(s)
      堀口浩史
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 視覚系の構造 Visual System Architecture2018

    • Author(s)
      堀口浩史
    • Organizer
      第546回慈眼会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] メラノプシンと羞明と脳科学と眼科医の苦悩2018

    • Author(s)
      堀口浩史
    • Organizer
      第7回クロスオーバーJAPAN
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Profound effect of age-related macular degeneration on visual acuity and the white matter projecting to locations of retinal damage2018

    • Author(s)
      Ogawa S, Pestilli F, Yoshimine S, Horiguchi H, Terao M, Makino T, Matsumoto K, Nakano T, Masuda Y
    • Organizer
      ARVO 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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