| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
A total of 49 Japanese patients with sebaceous carcinomas of the eyelid participated in the study. DNA was extracted for exome sequencing from both tumor tissues and blood samples obtained from 38 patients. As a result of the exome sequence analysis, we found that three previously reported genes were frequently mutated in our Japanese samples. We identified a novel gene that was mutated in approximately 20% of tumors. These results confirm that sebaceous carcinomas of the eyelid in the Japanese population have somatic mutations which have been previously reported in the studies of non-Japanese patients, and that major sebaceous carcinoma-related genes are shared across populations.
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